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Charles J. Vecht
Researcher at Pierre-and-Marie-Curie University
Publications - 74
Citations - 15103
Charles J. Vecht is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Epilepsy & Glioma. The author has an hindex of 37, co-authored 74 publications receiving 13367 citations. Previous affiliations of Charles J. Vecht include Erasmus University Rotterdam.
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Journal ArticleDOI
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp,Monika E. Hegi,Warren P. Mason,Martin J. van den Bent,Martin J.B. Taphoorn,Robert C. Janzer,Samuel K. Ludwin,Anouk Allgeier,Barbara Fisher,Karl Belanger,Peter Hau,Alba A. Brandes,J.M.M. Gijtenbeek,Christine Marosi,Charles J. Vecht,Karima Mokhtari,Pieter Wesseling,Salvador Villà,Elizabeth Eisenhauer,Thierry Gorlia,Michael Weller,Denis Lacombe,J. Gregory Cairncross,René-Olivier Mirimanoff +23 more
TL;DR: Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up, and a benefit of combined therapy was recorded in all clinical prognostic subgroups, including patients aged 60-70 years.
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Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951
Martin J. van den Bent,Alba A. Brandes,Martin J.B. Taphoorn,Johan M. Kros,Mathilde C.M. Kouwenhoven,Jean-Yves Delattre,Hans J.J.A. Bernsen,Marc Frenay,Cees C. Tijssen,Wolfgang Grisold,László Sipos,Roelien H. Enting,Pim J. French,Winand N.M. Dinjens,Charles J. Vecht,Anouk Allgeier,Denis Lacombe,Thierry Gorlia,Khê Hoang-Xuan +18 more
TL;DR: The addition of six cycles of PCV after 59.4 Gy of RT increases both OS and PFS in anaplastic oligodendroglial tumors, and 1p/19q-codeleted tumors derive more benefit from adjuvant PCV compared with non-1p/ 19q-deleted tumors.
Journal ArticleDOI
Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery
Charles J. Vecht,H. Haaxma-Reiche,Evert M. Noordijk,George W. Padberg,J. H. C. Voormolen,F. H. Hoekstra,J. T. J. Tans,N. Lambooij,J. A. L. Metsaars,A. R. Wattendorff,Ronald Brand,Jo Hermans +11 more
TL;DR: It is coclude that patients with single brain metastasis and stable extracranial tumor activity should be treated with surgical excision and radiotherapy, and that radiotherapy alone appears to be sufficient.
Journal ArticleDOI
Prognostic Factors for Survival in Adult Patients With Cerebral Low-Grade Glioma
Francesco Pignatti,Martin J. van den Bent,Desmond Curran,C. Debruyne,Richard Sylvester,Patrick Therasse,D Afra,Philippe Cornu,Michel Bolla,Charles J. Vecht,A.B.M.F. Karim +10 more
TL;DR: In adult patients with LGG, older age, astrocytoma histology, presence of neurologic deficits before surgery, largest tumor diameter, and tumor crossing the midline were important prognostic factors for survival and can be used to identify low-risk and high-risk patients.
Journal ArticleDOI
Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial
Martin J. van den Bent,Antoine F. Carpentier,Alba A. Brandes,Marc Sanson,Martin J B Taphoorn,Hans J.J.A. Bernsen,Marc Frenay,Cees C. Tijssen,Wolfgang Grisold,Laslo Sipos,H. Haaxma-Reiche,Johannes M. Kros,Mathilde C.M. Kouwenhoven,Charles J. Vecht,Anouk Allgeier,Denis Lacombe,Thierry Gorlia +16 more
TL;DR: Adjuvant PCV chemotherapy does not prolong OS but does increase PFS in anaplastic oligodendroglioma, and combined loss of 1p/19q identifies a favorable subgroup of oligodENDroglial tumors.