Charles L. Loprinzi

TL;DR: A framework exists on a framework for the definition and classification of cancer cachexia, a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment.

TL;DR: In this paper, the authors conducted a randomized, double-blind trial to determine the effect of aspirin on the incidence of colorectal adenomas, which was terminated early by an independent data and safety monitoring board when statistically significant results were reported during a planned interim analysis.

TL;DR: Patients with high-risk resected colon cancer obtain benefit from FU-based therapy across subsets of age, sex, location, T stage, nodal status, and grade, which may improve patients' and physicians' understanding of the potential benefits of adjuvant therapy.

TL;DR: Although the CIPN trials are inconclusive regarding tricyclic antidepressants (such as nortriptyline), gabapentin, and a compounded topical gel containing baclofen, amitriptylines HCL, and ketamine, these agents may be offered on the basis of data supporting their utility in other neuropathic pain conditions given the limited other CIPn treatment options.

TL;DR: Venlafaxine is an effective non-hormonal treatment for hot flashes, though the efficacy must be balanced against the drug's side-effects, as well as other related antidepressants for the treatment of hot flashes.