C
Charles N. Serhan
Researcher at Brigham and Women's Hospital
Publications - 761
Citations - 95609
Charles N. Serhan is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Inflammation & Lipoxin. The author has an hindex of 158, co-authored 728 publications receiving 84810 citations. Previous affiliations of Charles N. Serhan include Karolinska Institutet & Harvard University.
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Resolving inflammation : dual anti-inflammatory and pro-resolution lipid mediators
TL;DR: New cellular and molecular mechanisms for the resolution of inflammation are presented, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins, which have anti-inflammatory and pro-resolution properties.
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Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
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Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
TL;DR: The multiple interaction of lipoxygenases generates compounds that can regulate specific cellular responses of importance in inflammation and immunity.
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Pro-resolving lipid mediators are leads for resolution physiology
TL;DR: The mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions are covered.
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Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Charles N. Serhan,Song Hong,Karsten Gronert,Sean P. Colgan,Pallavi R. Devchand,Gudrun E. Mirick,Rose-Laure Moussignac +6 more
TL;DR: It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.