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Charles R. Mackay
Researcher at Monash University, Clayton campus
Publications - 294
Citations - 55409
Charles R. Mackay is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 106, co-authored 272 publications receiving 50300 citations. Previous affiliations of Charles R. Mackay include University of Melbourne & Takeda Pharmaceutical Company.
Papers
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Journal ArticleDOI
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Kendle M. Maslowski,Angélica T. Vieira,Angélica T. Vieira,Aylwin Ng,Jan Kranich,Frederic Sierro,Di Yu,Heidi C. Schilter,Heidi C. Schilter,Michael S. Rolph,Fabienne Mackay,Fabienne Mackay,David Artis,Ramnik J. Xavier,Ramnik J. Xavier,Mauro M. Teixeira,Charles R. Mackay +16 more
TL;DR: It is shown that SCFA–GPR43 interactions profoundly affect inflammatory responses, and GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses.
Journal ArticleDOI
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
Journal ArticleDOI
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
TL;DR: It is demonstrated that chemokine receptors are markers of naive and polarized T cell subsets and suggested that flexible programs of chemokin receptor gene expression may control tissue-specific migration of effector T cells.
Book ChapterDOI
The role of short-chain fatty acids in health and disease.
Jian Tan,Craig R. M. McKenzie,Maria Potamitis,Alison N. Thorburn,Charles R. Mackay,Laurence Macia +5 more
TL;DR: The role of SCFAs as a major player in maintenance of gut and immune homeostasis is highlighted, and their levels are regulated by diet are provided a new basis to explain the increased prevalence of inflammatory disease in Westernized countries.
Journal ArticleDOI
T-cell function and migration. Two sides of the same coin.
TL;DR: This review will concentrate on the migration of T cells, which are at the heart of most adaptive immune responses, since T cells respond to pathogens only on direct contact with pathogen-derived antigen.