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Author

Chauveau Bruno

Bio: Chauveau Bruno is an academic researcher. The author has an hindex of 2, co-authored 4 publications receiving 21 citations.

Papers
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Patent
04 Jun 2004
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

11 citations

Patent
25 Oct 1996
TL;DR: In this article, the authors proposed a new intermediary for the hemisynthesis of taxanes and their preparation processes, which enables to obtain a product such as PACLITAXELTM in only five steps from products available in the market, compared to nine steps for processes of the prior art.
Abstract: The present invention relates to new intermediaries for the hemisynthesis of taxanes and their preparation processes. It relates particularly to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXELTM in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.

8 citations

Patent
02 Dec 1998
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

2 citations

Patent
27 Oct 1995
TL;DR: In this article, the authors present an invention concerne de nouveaux intermediaires for l'hemisynthese de taxanes and leurs procedes de preparation.
Abstract: La presente invention concerne de nouveaux intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation. Il s'agit notamment de derives d'oxazolidines ou d'oxazolidinones, ainsi que de nouveaux derives de la baccatine Ill. Le procede general de synthese des taxanes selon l'invention permet d'obtenir un produit tel que le PACLITAXEL en seulement cinq etapes a partir de produits disponibles dans le commerce, contre generalement neuf etapes pour les procedes de l'etat de la technique.

Cited by
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Patent
06 Jul 2012
TL;DR: In this article, a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil is presented.
Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture which is a fish oil or which is derived from fish oil, which process comprises the steps of: (i) purifying the feed mixture in a chromatographic separation step, to obtain a first intermediate product; and (ii) purifying the first intermediate product obtained in (i) in a simulated or actual moving bed chromatographic separation step, to obtain a second intermediate product; and (iii) purifying the second intermediate product obtained in (ii) in a simulated or actual moving bed chromatographic separation step, to obtain the PUFA product; wherein an aqueous organic solvent is used as eluent in each separation step; saturated and/or monounsaturated fatty acids present in the feed mixture are removed in the first separation step; the PUFA product is separated from different components of the feed mixture in steps (ii) and (iii); and the PUFA product obtained in the third separation step contains EPA or an EPA derivative in an amount greater than 90 wt%.

14 citations

Patent
24 Dec 2010
TL;DR: In this paper, a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, was presented.
Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone.

11 citations

Patent
04 Jun 2004
TL;DR: In this paper, the present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative, and is related to the present paper.
Abstract: The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

11 citations

Patent
09 Jan 2014
TL;DR: In this paper, a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture is presented, where the PUFA product is other than alpha-linolenic acid.
Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using an eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.0, wherein the PUFA product is other than alpha-linolenic acid (ALA), gamma-linolenic acid (GLA), linoleic acid, an ALA mono- di- or triglyceride, a GLA mono- di- or triglyceride, a linoleic acid mono- di- or triglyceride, an ALA C1-C4 alkyl ester, a GLA C1-C4 alkyl ester or a linoleic acid C1-C4 alkyl ester or a mixture thereof.

10 citations

Patent
07 Jan 2014
TL;DR: In this paper, a process for recovering a first polyunsaturated fatty acid from a feed mixture, wherein the feed mixture comprises at least a second fatty acid in addition to the first PUFA, was proposed.
Abstract: The invention relates to a process for recovering a first polyunsaturated fatty acid from a feed mixture, wherein the feed mixture comprises at least a second fatty acid in addition to the first polyunsaturated fatty acid, the process comprising: - performing a main step of chromatographic separation using an aqueous organic eluent and thereby collecting a first stream of eluent enriched in the first polyunsaturated fatty acid and a second stream of eluent enriched in the second fatty acid; - subjecting the second stream of eluent to a concentration step so as to obtain a stream of concentrated fatty acids on the one hand and a depleted second stream of eluent on the other hand, wherein the water-to-organic ratio of the depleted second stream of eluent is lower than the water-to-organic ratio of the second stream of eluent; recycling at least part of the depleted second stream of eluent to use it in the main step of chromatographic separation.

9 citations