Chenchugari Sridhar

Bio: Chenchugari Sridhar is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Vitex altissima & Agnuside. The author has an hindex of 2, co-authored 2 publications receiving 88 citations.

New acylated iridoid glucosides from Vitex altissima.

Abstract: Six new iridoid glucosides, 6'-O-trans-feruloylnegundoside (1), 6'-O-trans-caffeoylnegundoside (2), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoylgardoside (3), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoyl-8-epiloganic acid (4), 2'-O-p-hydroxybenzoyl gardoside (5), and 2'-O-p-hydroxybenzoyl-8-epiloganic acid (6), along with two known iridoids, agnuside and negundoside, have been isolated from the ethyl acetate extractive of the leaves of Vitex altissima. The structures of these compounds were elucidated on the basis of spectral data interpretation. These isolates did not exhibit significant 5-lipoxygenase enzyme inhibitory activity, but compounds 2-4 showed potent antioxidant activity by both the superoxide (NBT riboflavin photoreduction) free-radical-scavenging and DPPH-radical-scavenging methods. Compounds 1, 2, and negundoside were evaluated in a rat paw edema assay.

Naturally Occurring Iridoids. A Review, Part 1

Abstract: A compilation of new naturally occurring iridoid glycosides, iridoid aglycones, iridoid derivatives and bis-iridoids reported during 1994-2005 is provided with available physical and spectral data: mp, [alpha]D, UV, IR, 1H- and 13C-NMR as well as natural source with family and references. 418 compounds with 202 references are cited.

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Abstract: Naturally occurring new secoiridoids published during 1994-2005 are reviewed with available physical and spectral data: mp, [alpha](D), UV, IR, (1)H- and (13)C-NMR and plant source. The works on biological and pharmacological activity of naturally occurring iridoids and secoiridoids reported during 1998-2005 are also reviewed. Bioactivities like antiallergic, antiarthritis, antibacterial, anticancer, anticoagulant, anticomplement, antifungal, antiinflammatory, antioxidative, antiprotozoal, antispasmodic, antiviral, immunomodulatory, neuroprotective, nerve growth factor potentiating and wound healing activities are highlighted.

The genus Vitex: A review.

Abstract: The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Essential oils, flavonoids, iridoid glycosides, diterpenoides and ligans constitute major classes of phytoconstituents of the genus. A few species of this genus have medicinal value, among these, leaves and fruits of V. agnus-castus Linn. (Verbenaceae) has been traditionally used in treatment of women complaints. V. agnus-castus has also been included in herbal remedies, which are in clinical use to regulate the menstrual cycle, reduce premenstrual symptom tension and anxiety, treat some menopausal symptoms as well as to treat hormonally induced acne. Despite a long tradition of use of some species, the genus has not been explored properly. In the concluding part, the future scope of Vitex species has been emphasized with a view to establish their multifarious biological activities and mode of action.