C
Cheng Cheng Zhang
Researcher at University of Texas Southwestern Medical Center
Publications - 134
Citations - 17355
Cheng Cheng Zhang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 41, co-authored 120 publications receiving 15134 citations. Previous affiliations of Cheng Cheng Zhang include University of Texas at Austin & Guangdong University of Technology.
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Journal ArticleDOI
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
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Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation
Eva Tomas,Tsu-Shuen Tsao,Asish K. Saha,Heather E. Murrey,Cheng Cheng Zhang,Samar I. Itani,Harvey F. Lodish,Neil B. Ruderman,Neil B. Ruderman +8 more
TL;DR: Both in vivo and in vitro, activation of AMPK was the first effect of gACRP30 and was transient, whereas alterations in malonyl CoA and ACC occurred later and were more sustained, indicating that gAC RP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation ofAMPK and perhaps other signal transduction proteins.
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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
Tugba Simsek,Fatih Kocabas,Junke Zheng,Ralph J. DeBerardinis,Ahmed I. Mahmoud,Eric N. Olson,Jay W. Schneider,Cheng Cheng Zhang,Hesham A. Sadek +8 more
TL;DR: It is shown that LT-HSCs utilize glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands and that Meis1 regulates HSC metabolism through transcriptional activation of Hif-1alpha.
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Hypoxia induces heart regeneration in adult mice
Yuji Nakada,Diana C. Canseco,Suwannee Thet,Salim Abdisalaam,Aroumougame Asaithamby,Celio X.C. Santos,Ajay M. Shah,Hua Zhang,James E. Faber,Michael Kinter,Luke I. Szweda,Chao Xing,Zeping Hu,Ralph J. DeBerardinis,Gabriele G. Schiattarella,Joseph A. Hill,Orhan K. Öz,Zhigang Lu,Cheng Cheng Zhang,Wataru Kimura,Wataru Kimura,Hesham A. Sadek +21 more
TL;DR: It is demonstrated that the endogenous regenerative properties of the adult mammalian heart can be reactivated by exposure to gradual systemic hypoxaemia, and the potential therapeutic role of hypoxia in regenerative medicine is highlighted.
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Phagocytosis checkpoints as new targets for cancer immunotherapy.
TL;DR: An improved understanding of the tumour-intrinsic processes that inhibit essential immune surveillance processes, such as phagocytosis and innate immune sensing, could pave the way for the development of highly effective combination immunotherapy strategies that modulate both innate and adaptive antitumour immune responses.