C
Cheng-Fu Kao
Researcher at Academia Sinica
Publications - 46
Citations - 2853
Cheng-Fu Kao is an academic researcher from Academia Sinica. The author has contributed to research in topics: Chromatin & Histone H2B. The author has an hindex of 19, co-authored 44 publications receiving 2601 citations. Previous affiliations of Cheng-Fu Kao include University of New Mexico & National Taiwan University.
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Journal ArticleDOI
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
Karl W. Henry,Anastasia Wyce,Wan Sheng Lo,Laura J. Duggan,N. C. Tolga Emre,Cheng-Fu Kao,Lorraine Pillus,Ali Shilatifard,Mary Ann Osley,Shelley L. Berger +9 more
TL;DR: The results suggest that the histone H2B ubiquitylation state is dynamic during transcription, and that the sequence of histone modifications helps to control transcription.
Journal ArticleDOI
Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II
Tiaojiang Xiao,Cheng-Fu Kao,Nevan J. Krogan,Zu-Wen Sun,Jack Greenblatt,Mary Ann Osley,Brian D. Strahl +6 more
TL;DR: A role for Rad6 and H2B ubiquitylation during the elongation cycle of transcription is indicated and a mechanism by which H3 methylation may be regulated is suggested.
Journal ArticleDOI
H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation
Alastair B. Fleming,Cheng-Fu Kao,Cory Hillyer,Michael Pikaart,Michael Pikaart,Mary Ann Osley +5 more
TL;DR: H2B ubiquitylation is required for efficient reassembly of nucleosomes during RNA polymerase II (Pol II)-mediated transcription elongation in yeast and Spt16 regulates the formation of ubiquitylated H2B both globally and at the GAL1 gene.
Journal ArticleDOI
Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B
TL;DR: The data suggest that Rad6 and SAGA function independently during galactose induction, and that the staged recruitment of these two factors to the GAL1 promoter regulates the ubiquitylation and deubiquitylation of H2B.
Journal ArticleDOI
The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription
Jacques Bonnet,Chen-Yi Wang,Tiago Baptista,Stéphane D. Vincent,Wei-Chun Hsiao,Matthieu Stierle,Cheng-Fu Kao,Laszlo Tora,Didier Devys +8 more
TL;DR: This study uncovers a new function for SAGA as a bone fide cofactor for all RNA polymerase II transcription by monitoring the genome-wide distribution of histone H3K9 acetylation and H2B ubiquitination and indicating a highly dynamic association of the complex with chromatin.