C
Cheng Ming Chiang
Researcher at University of Texas Southwestern Medical Center
Publications - 119
Citations - 9790
Cheng Ming Chiang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Transcription (biology) & General transcription factor. The author has an hindex of 48, co-authored 109 publications receiving 8579 citations. Previous affiliations of Cheng Ming Chiang include Rockefeller University & National Institutes of Health.
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Journal ArticleDOI
The general transcription machinery and general cofactors.
Mary C. Thomas,Cheng Ming Chiang +1 more
TL;DR: These cofactors are capable of repressing basal transcription when activators are absent and stimulating transcription in the presence of activators, with emphasis on the events occurring after the chromatin has been remodeled but prior to the formation of the first phosphodiester bond.
Journal ArticleDOI
The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation
Shwu Yuan Wu,Cheng Ming Chiang +1 more
TL;DR: The dual role of Brd4 in gene activation and repression illustrates how a dynamic chromatin-binding adaptor is able to recruit distinct transcriptional regulators to modulate promoter activity through cell cycle progression.
Journal ArticleDOI
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
Shaokun Shu,Charles Y. Lin,Housheng Hansen He,Robert M. Witwicki,Doris P. Tabassum,Justin M. Roberts,Michalina Janiszewska,Sung Jin Huh,Yi Liang,Jeremy Ryan,Ernest Doherty,Hisham Mohammed,Hao Guo,Daniel G. Stover,Muhammad B. Ekram,Guillermo Peluffo,Jonathan D. Brown,Clive D'Santos,Ian E. Krop,Deborah A. Dillon,Michael R. McKeown,Christopher J. Ott,Jun Qi,Min Ni,Prakash Rao,Melissa Duarte,Shwu Yuan Wu,Cheng Ming Chiang,Lars Anders,Richard A. Young,Eric P. Winer,Antony Letai,William T. Barry,Jason S. Carroll,Henry W. Long,Myles Brown,X. Shirley Liu,X. Shirley Liu,Clifford A. Meyer,James E. Bradner,James E. Bradner,Kornelia Polyak,Kornelia Polyak +42 more
TL;DR: In this article, the preferential sensitivity of triple negative breast cancer (TNBC) cells to BET bromodomain inhibition in vitro and in vivo has been investigated and a rationale for clinical investigation and further motivation to understand mechanisms of resistance.
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SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Bhaskar Ponugoti,Dong-Hyun Kim,Zhen Xiao,Zachary Smith,Ji Miao,Mengwei Zang,Shwu Yuan Wu,Cheng Ming Chiang,Timothy D. Veenstra,Jongsook Kim Kemper +9 more
TL;DR: It is reported that SREBP-1c, a key lipogenic activator, is an in vivo target of SIRT1, and acetylation levels were elevated in diet-induced obese mice, and hepatic overexpression of SIRC1 or treatment with resveratrol daily for 1 week decreased acetylated SRE BP- 1c levels with beneficial functional outcomes.
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Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators
TL;DR: The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TAFID is now described and may be a co-activator that mediates a response to multiple activators through a distinct mechanism.