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Chengfeng Yang
Researcher at University of Kentucky
Publications - 66
Citations - 2855
Chengfeng Yang is an academic researcher from University of Kentucky. The author has contributed to research in topics: Carcinogenesis & Cancer. The author has an hindex of 29, co-authored 62 publications receiving 2302 citations. Previous affiliations of Chengfeng Yang include Michigan State University.
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Journal ArticleDOI
The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy
Brock Humphries,Chengfeng Yang +1 more
TL;DR: It is concluded that miR-200 family may serve as novel targets for the therapy of multiple types of cancer.
Journal ArticleDOI
Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer
Maria Soledad Sosa,Cynthia Lopez-Haber,Chengfeng Yang,HongBin Wang,Mark A. Lemmon,John M. Busillo,Jiansong Luo,Jeffrey L. Benovic,Andres J. Klein-Szanto,Hiroshi Yagi,J. Silvio Gutkind,Ramon Parsons,Marcelo G. Kazanietz +12 more
TL;DR: The PIP(3)-Gβγ-dependent Rac-GEF P-Rex1 is identified as an essential mediator of Rac1 activation, motility, cell growth, and tumorigenesis driven by ErbB receptors in breast cancer cells.
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Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b
Zhishan Wang,Yong Zhao,Eric Smith,Gregory J. Goodall,Paul A. Drew,Thomas Brabletz,Chengfeng Yang +6 more
TL;DR: Findings establish for the first time a causal role for depletion of miR-200b expression in human cell malignant transformation and tumor formation resulting from arsenic exposure.
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Perfluorooctanoic Acid Effects on Steroid Hormone and Growth Factor Levels Mediate Stimulation of Peripubertal Mammary Gland Development in C57Bl/6 Mice
TL;DR: Results indicate that PFOA stimulates mammary gland development in C57Bl/6 mice by promoting steroid hormone production in ovaries and increasing the levels of a number of growth factors in mammary glands, which is independent of the expression of PPARalpha.
Journal ArticleDOI
Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C.
Qiaoyuan Yang,Zhigang Jie,Hong Cao,Anne R. Greenlee,Chengfeng Yang,Fei Zou,Yiguo Jiang,Yiguo Jiang +7 more
TL;DR: It is revealed that let-7a is significant in suppressing gastric cancer growth in vivo and in vitro and provided the first evidence that RAB40C is negatively regulated by let- 7a at the posttranscriptional level via binding to the 3'-untranslated region of RAB 40C messenger RNA in gastriccancer.