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Chengge Gao
Researcher at Xi'an Jiaotong University
Publications - 51
Citations - 2008
Chengge Gao is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Major depressive disorder & Anxiety. The author has an hindex of 19, co-authored 49 publications receiving 1499 citations.
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Journal ArticleDOI
Sparse whole-genome sequencing identifies two loci for major depressive disorder
Na Cai,Tim B. Bigdeli,Warren W. Kretzschmar,Yihan Li,Jieqin Liang,Li Song,Jingchu Hu,Qibin Li,Wei Jin,Zhenfei Hu,Guangbiao Wang,Linmao Wang,Puyi Qian,Yuan Liu,Tao Jiang,Yao Lu,Xiuqing Zhang,Ye Yin,Yingrui Li,Xun Xu,Jingfang Gao,Mark Reimers,Todd Webb,Brien P. Riley,Silviu Alin Bacanu,Roseann E. Peterson,Yiping Chen,Hui Zhong,Zhengrong Liu,Gang Wang,Sun Jing,Hong Sang,Guoqing Jiang,Xiaoyan Zhou,Yi Li,Wei Zhang,Xueyi Wang,Xiang Fang,Runde Pan,Guodong Miao,Qiwen Zhang,Jian Hu,Fengyu Yu,Bo Du,Wenhua Sang,Keqing Li,Guibing Chen,Min Cai,Lijun Yang,Donglin Yang,Baowei Ha,Xiaohong Hong,Hong Deng,Gongying Li,Kan Li,Yan Song,Shugui Gao,Jinbei Zhang,Zhaoyu Gan,Huaqing Meng,Jiyang Pan,Chengge Gao,Kerang Zhang,Ning Sun,Youhui Li,Qihui Niu,Yutang Zhang,Tieqiao Liu,Chunmei Hu,Zhen Zhang,L Lv,Jicheng Dong,Xiaoping Wang,Ming Tao,Xumei Wang,Jing Xia,Han Rong,Qiang He,Tiebang Liu,Guoping Huang,Qiyi Mei,Zhenming Shen,Liu Ying,Jianhua Shen,Tian Tian,Xiaojuan Liu,Wenyuan Wu,Danhua Gu,Guangyi Fu,Jianguo Shi,Yunchun Chen,Xiangchao Gan,Lanfen Liu,Lina Wang,Fuzhong Yang,Enzhao Cong,Jonathan Marchini,Huanming Yang,Jian Wang,Shenxun Shi,Shenxun Shi,Richard Mott,Qi Xu,Jun Wang,Jun Wang,Jun Wang,Kenneth S. Kendler,Jonathan Flint,Jonathan Flint +108 more
TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.
Journal ArticleDOI
Metagenome-wide association of gut microbiome features for schizophrenia.
Feng Zhu,Yanmei Ju,Wei Wang,Qi Wang,Ruijin Guo,Qingyan Ma,Qiang Sun,Yajuan Fan,Yuying Xie,Zai Yang,Zhuye Jie,Binbin Zhao,Liang Xiao,Lin Yang,Tao Zhang,Junqin Feng,Liyang Guo,Xiaoyan He,Yunchun Chen,Ce Chen,Chengge Gao,Xun Xu,Huanming Yang,Jian Wang,Yonghui Dang,Lise Madsen,Susanne Brix,Karsten Kristiansen,Huijue Jia,Xiancang Ma +29 more
TL;DR: The authors present a metagenome-wide association study of schizophrenia (SZ) in human cohorts and identify SZ-associated specific gut-brain functional modules and pathways including SCFAs and neurotransmitters, which provide new leads for further investigations in cohort studies and animal models.
Journal ArticleDOI
Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice
Feng Zhu,Ruijin Guo,Wei Wang,Yanmei Ju,Qi Wang,Qingyan Ma,Qiang Sun,Yajuan Fan,Yuying Xie,Zai Yang,Zhuye Jie,Binbin Zhao,Liang Xiao,Lin Yang,Tao Zhang,Bing Liu,Liyang Guo,Xiaoyan He,Yunchun Chen,Ce Chen,Chengge Gao,Xun Xu,Huanming Yang,Jian Wang,Yonghui Dang,Lise Madsen,Susanne Brix,Karsten Kristiansen,Huijue Jia,Xiancang Ma +29 more
TL;DR: The study suggests that the abnormalities in the composition of gut microbiota contribute to the pathogenesis of schizophrenia partially through the manipulation of tryptophan–kynurenine metabolism.
Journal ArticleDOI
Population-based and family-based association studies of ZNF804A locus and schizophrenia
R Zhang,Shemin Lu,Chuan Qiu,Xiao-Gang Liu,Chengge Gao,Tingwei Guo,Robert K. Valenzuela,Hong-Wen Deng,Jie Ma +8 more
TL;DR: These established iPSC lines from schizophrenia patients with a defined DISC1 mutation will provide a useful resource for investigating the function of DISC 1 in human neurodevelopment and serve as an entry point to clarify the molecular and cellular pathogenesis of schizophrenia.
Journal ArticleDOI
Targeting of NMDA Receptors in the Treatment of Major Depression
TL;DR: Recent findings concerning the role of glutamatergic signaling in the neurobiology of MDD and potential, novel therapeutic drugs, such as ketamine, memantine, AZD6765, traxoprodil, MK-0657, GLYX-13, NRX-1047, D-cycloserine, sarcosine, all of which target this system are reviewed.