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Chenglong Wang
Researcher at Shanghai Jiao Tong University
Publications - 18
Citations - 403
Chenglong Wang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: microRNA & Chemistry. The author has an hindex of 9, co-authored 14 publications receiving 267 citations.
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Journal ArticleDOI
MicroRNA-145 attenuates TNF- α -driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4
Guoli Hu,Xiaoying Zhao,Chuandong Wang,Yiyun Geng,Jingyu Zhao,Jiajia Xu,Bin Zuo,Chen Zhao,Chenglong Wang,Xiaoling Zhang +9 more
TL;DR: A novel regulatory mechanism underlying TNF-α-triggered cartilage degradation is elucidated and the potential utility of miR-145 and MKK4 as therapy targets for OA is demonstrated.
Journal ArticleDOI
Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells.
TL;DR: It is suggested that MALAT1 acts to regulate Osx expression through targeting miR‐143; thus, it is considered as a positive regulator in hBMSC osteogenic differentiation.
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Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.
Chenglong Wang,Fei Xiao,Chuandong Wang,Junfeng Zhu,Chao Shen,Bin Zuo,Hui Wang,De Li,X. Wang,Wei-Jia Feng,Zhuokai Li,Guoli Hu,Xiaoling Zhang,Xiaodong Chen +13 more
TL;DR: It was found that Grem2 expression was upregulated by BMP‐2 within the range of 0–1 μg/mL, and significant increases were evident at 48, 72, and 96 h after B MP‐2 treatment, whereas overexpression of Gremlin2 had the opposite trend.
Journal ArticleDOI
Mechanical stimulation promote the osteogenic differentiation of bone marrow stromal cells through epigenetic regulation of Sonic Hedgehog
Chuandong Wang,Shengzhou Shan,Chenglong Wang,Jing Wang,Jiao Li,Guoli Hu,Kerong Dai,Qingfeng Li,Xiaoling Zhang +8 more
TL;DR: It is demonstrated, for the first time, that mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b, and the therapeutic inhibition of Dna3b may be an efficient strategy for enhancing bone formation under mechanical unloading.
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LncRNA-CIR promotes articular cartilage degeneration in osteoarthritis by regulating autophagy
TL;DR: Overall, lncRNA-CIR played a negative role in the OA process by activating autophagy, and si-lncRNAs treated joints exhibited fewer OA changes than saline-treated joints.