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Chengping Hu
Researcher at Central South University
Publications - 196
Citations - 9635
Chengping Hu is an academic researcher from Central South University. The author has contributed to research in topics: Lung cancer & Internal medicine. The author has an hindex of 27, co-authored 173 publications receiving 7654 citations.
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Journal ArticleDOI
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
Caicun Zhou,Yi-Long Wu,Gongyan Chen,Jifeng Feng,Xiaoqing Liu,Changli Wang,Shucai Zhang,Jie Wang,Songwen Zhou,Shengxiang Ren,Shun Lu,Li Zhang,Chengping Hu,Chunhong Hu,Yi Luo,Lei Chen,Ming Ye,Jian'An Huang,Xiuyi Zhi,Yiping Zhang,Qingyu Xiu,Jun Ma,Changxuan You +22 more
TL;DR: It is suggested that erlotinib is important for first-line treatment of patients with advanced EGFR mutation-positive NSCLC, and was associated with more favourable tolerability than standard chemotherapy.
Journal ArticleDOI
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial
Yi-Long Wu,Caicun Zhou,Chengping Hu,Jifeng Feng,Shun Lu,Yunchao Huang,Wei Li,Mei Hou,Jian Hua Shi,Kye Young Lee,Chong-Rui Xu,Dan Massey,MI-Young Kim,Yang Shi,Sarayut Lucien Geater +14 more
TL;DR: Afatinib significantly improves progression-free survival with a tolerable and manageable safety profile in Asian patients with EGFR mutation-positive advanced lung NSCLC and should be considered as a first-line treatment option for this patient population.
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Final overall survival results from a randomised, Phase III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802)
Caicun Zhou,Yi-Long Wu,Gongyan Chen,Ji Feng Feng,Xiaoqing Liu,Changli Wang,Shucai Zhang,Jian Wang,Songwen Zhou,Shengxiang Ren,Shaoyong Lu,Lin Zhang,Chengping Hu,Yi Luo,Lei Chen,Ming Ye,Jian'An Huang,Xiuyi Zhi,Yiping Zhang,Qingyu Xiu,Jun Ma,Changxuan You +21 more
TL;DR: The significant OS benefit observed in patients treated with EGFR-TKI emphasises its contribution to improving survival of EGFR mutation-positive advanced non-small-cell lung cancer patients, suggesting that erlotinib should be considered standard first-line treatment of EGfr mutant patients and EGFR -TKI treatment following first- line therapy also brings significant benefits to those patients.
Journal ArticleDOI
Nivolumab Versus Docetaxel in a Predominantly Chinese Patient Population With Previously Treated Advanced NSCLC: CheckMate 078 Randomized Phase III Clinical Trial.
Yi-Long Wu,Shun Lu,Ying Cheng,Caicun Zhou,Jie Wang,Tony Mok,Li Zhang,Hai Yan Tu,Lin Wu,Jifeng Feng,Yiping Zhang,Alexander Luft,Jianying Zhou,Zhiyong Ma,You Lu,Chengping Hu,Yuankai Shi,Christine Baudelet,Junliang Cai,Jianhua Chang +19 more
TL;DR: This is the first phase III study in a predominantly Chinese population reporting results with a programmed death 1 inhibitor and nivolumab improved OS versus docetaxel and results were consistent with global CheckMate 017 and 057 studies.
Journal ArticleDOI
Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China
Hongjie Yu,Zhancheng Gao,Zijian Feng,Yuelong Shu,Nijuan Xiang,Lei Zhou,Yang Huai,Luzhao Feng,Zhibin Peng,Zhongjie Li,Cuiling Xu,Junhua Li,Chengping Hu,Qun Li,Xiaoling Xu,Xuecheng Liu,Zigui Liu,Longshan Xu,Yusheng Chen,Huiming Luo,Li-ping Wei,Xianfeng Zhang,Jian-bao Xin,Junqiao Guo,Qiuyue Wang,Zhengan Yuan,Longnv Zhou,Kunzhao Zhang,Wei Zhang,Jinye Yang,Xiao-ning Zhong,Shichang Xia,Lanjuan Li,Jinquan Cheng,Erdang Ma,Pingping He,Shui Shan Lee,Yu Wang,Timothy M. Uyeki,Weizhong Yang +39 more
TL;DR: The clinical course of Chinese H5N1 cases is characterized by fever and cough initially, with rapid progression to lower respiratory disease, and decreased platelet count, elevated LDH level, ARDS and cardiac failure were associated with fatal outcomes.