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Chenyao Wang
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 25
Citations - 588
Chenyao Wang is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Phosphorylation & Medicine. The author has an hindex of 9, co-authored 15 publications receiving 329 citations. Previous affiliations of Chenyao Wang include Cleveland Clinic & Chinese Academy of Sciences.
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Journal ArticleDOI
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
Deyi Zhang,Wei Wang,Xiujie Sun,Daqian Xu,Chenyao Wang,Qian Zhang,Huafei Wang,Wenwen Luo,Yan Chen,Huaiyong Chen,Zhixue Liu +10 more
TL;DR: It is shown that AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388, uncovering a novel mechanism of Autophagy regulation.
Journal ArticleDOI
Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
Chenyao Wang,Huafei Wang,Deyi Zhang,Wenwen Luo,Ruilong Liu,Daqian Xu,Lei Diao,Lujian Liao,Zhixue Liu,Zhixue Liu +9 more
TL;DR: A late role for ULK in auotophagosome–lysosome fusion is demonstrated and the significance of the mutual regulation of macroautophagy and CMA in maintaining the balance of autophagy is revealed.
Journal ArticleDOI
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance
Ruilong Liu,Wenfeng Li,Bangbao Tao,Xiongjun Wang,Zhuo Yang,Yajuan Zhang,Chenyao Wang,Rongzhi Liu,Hong Gao,Ji Liang,Weiwei Yang +10 more
TL;DR: It is shown that activation of EGFR induces phosphorylation of this enzyme at Y481 to activate the pentose phosphate pathway, which consequently reduces ROS and accelerates DNA synthesis to promote tumor growth and radioresistance.
Journal ArticleDOI
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity
Daqian Xu,Zheng Wang,Chenyao Wang,Deyi Zhang,Huida Wan,Zilong Zhao,Jin Gu,Yong‐Xian Zhang,Zhigang Li,Kaiyang Man,Yi Pan,Zhi‐Fei Wang,Zun-Ji Ke,Zhixue Liu,Lujian Liao,Yan Chen,Yan Chen +16 more
TL;DR: PAQR3 can not only enhance the capacity of pro‐autophagy class III PI3K due to its scaffold function, but also integrate AMPK signal to activation of ATG14L‐linked VPS34 complex upon glucose starvation.
Journal ArticleDOI
CRTH2 promotes endoplasmic reticulum stress‐induced cardiomyocyte apoptosis through m‐calpain
Shengkai Zuo,Shengkai Zuo,Deping Kong,Chenyao Wang,Jiao Liu,Yuanyang Wang,Qiangyou Wan,Shuai Yan,Jian Zhang,Juan Tang,Qianqian Zhang,Luheng Lyu,Luheng Lyu,Xin Li,Zhixin Shan,Qian Li,Yujun Shen,Ying Yu,Ying Yu +18 more
TL;DR: It is demonstrated that CRTH2 disruption markedly improved cardiac recovery in mice postmyocardial infarction and doxorubicin challenge by suppressing cardiomyocyte apoptosis, suggesting thatCRTH2 inhibition has therapeutic potential for ischemic cardiopathy.