Cheryl M. Coffin

TL;DR: In this paper, the authors report their experience with 84 cases occurring in the soft tissues and viscera of 48 female patients and 36 male patients between the ages of 3 months and 46 years (mean, 9.7 years; median, 9 years).

TL;DR: A subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymphoma kinase (ALK) and other markers to identify potential pathologic prognostic features found ALK reactivity may be a favorable prognostic indicator in IMT and abdominopelvic IMTs recur more frequently.

TL;DR: Abnormalities of ALK and p80 and evidence of chromosomal rearrangements of 2p23 occur in a significant proportion of IMTs and suggest that aneuploid IMT is a subset with more aggressive clinical behavior.

TL;DR: Anti-ALK staining seems to correlate with those IMTs that have the typical tri-patterned histologic appearance and clinical presentation, providing additional support to the premise that IMT is a distinctive clinicopathologic entity within the broad category of inflammatory pseudotumors.

TL;DR: The direct test for mutations in the RET protooncogene is the preferred method for screening MEN 2A kindreds and in family members who have inherited a RET mutation, total thyroidectomy is indicated, regardless of the plasma CT values.