Chester Merle Suter

Bio: Chester Merle Suter is an academic researcher. The author has contributed to research in topics: Metal sulfur dioxide complex & Sulfur. The author has an hindex of 1, co-authored 1 publications receiving 24 citations.

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Abstract: Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of covalent inhibitors of human neutrophil elastase (hNE). Evaluation of our ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed a selective and covalent hNE inhibitor: benzene-1,2-disulfonyl fluoride. Synthetic derivatization of the initial hit led to a more potent agent, 2-(fluorosulfonyl)phenyl fluorosulfate with IC50 0.24 μM and greater than 833-fold selectivity over the homologous neutrophil serine protease, cathepsin G. The optimized, yet simple benzenoid probe only modified active hNE and not its denatured form.

The Increased Basophilia of Tissue Proteins After Oxidation with Periodic Acid

Abstract: Oxidation by periodic acid (a 1% aqueous solution for 1 hour at 37°C.) greatly enhances the basophilic staining normally present in the keratinized portions of epidermis and hair. It also induces strong basophilia in purified fibrin and in the cytoplasm of smooth and striated muscle fibers, endothelium and the cells of the pancreatic islets and acini Proof is offered that this observed basophilia differs from that of either acid mucopolysaccharides or nucleoproteins. The conclusion is reached that, besides revealing polysaccharides occurring in tissue sections, periodic acid also brings about the formation of strongly acid, basophilic groups. These acid groups have not been identified, but since they may be formed most readily in regions of high sulfur content, it is suggested that sulfide and sulfhydryl groups may be oxidized to the corresponding sulfonic acids which could account for the observed characteristics of the basophilic substances.

Reprocessing of Spent Solvent of the UNEX Process

Abstract: A procedure was developed for conversion of spent UNEX solvent into a solid infusible resin, insoluble in aqueous alkali and acid solutions and organic solvents, by condensation with phenol and paraform. Incorporation of phenyl trifluoromethyl sulfone into the resin was confirmed by physicochemical methods. Resistance of the cured resin to high temperatures was proved by thermogravimetry. The developed procedure can also be applied to other organic wastes containing weakly reactive aromatic compounds such as nitrobenzotrifluoride, 1,2-dichlorobenzene, and nitrobenzene.

Synthesis and Structure of Fiber Forming Polymethylene Sulfones and Evaluation of Such a Polysulfone Fiber

Abstract: ing groups and on the frequency with which this substitution occurs in the basic polymethylene chain. It is known, for example, that the substitution of oxygen, sulfur, or carboxyt groups for a CH, group in polymethylene in general lowers the melting point compared to that of polymethylene, while the introduction of urethane, amide, or urea groups increases the melting point. z comparison of low molecular weight structures containing the latter groups with equivalent stilfones s s that the sulfones have