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Chi-Shuen Chu
Researcher at Rockefeller University
Publications - 17
Citations - 1041
Chi-Shuen Chu is an academic researcher from Rockefeller University. The author has contributed to research in topics: Chromatin & RNA polymerase II. The author has an hindex of 9, co-authored 15 publications receiving 810 citations. Previous affiliations of Chi-Shuen Chu include National Yang-Ming University & National Taiwan University.
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Journal ArticleDOI
TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases
Chih-Hung Hsu,Kai-Lin Peng,Kai-Lin Peng,Ming-Lun Kang,Yi-Ren Chen,Yu-Chih Yang,Chin-Hsien Tsai,Chin-Hsien Tsai,Chi-Shuen Chu,Chi-Shuen Chu,Yung-Ming Jeng,Yen-Ting Chen,Yen-Ting Chen,Feng Mao Lin,Hsien Da Huang,Yun-Yuh Lu,Yu-Ching Teng,Yu-Ching Teng,Shinn-Tsuen Lin,Ruo Kai Lin,Fan-Mei Tang,Sung Bau Lee,Huan Ming Hsu,Jyh-Cherng Yu,Pei-Wen Hsiao,Li-Jung Juan,Li-Jung Juan,Li-Jung Juan +27 more
TL;DR: It is shown that TET1, a dioxygenase involved in cytosine demethylation, is downregulated in prostate and breast cancer tissues, illustrating a mechanism by which TET 1 suppresses tumor development and invasion partly through downregulation of critical gene methylation.
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CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Yanwen Jiang,Ana Ortega-Molina,Huimin Geng,Hsia-Yuan Ying,Katerina Hatzi,Katerina Hatzi,Sara Parsa,Dylan R. McNally,Ling Wang,Ashley S. Doane,Xabier Agirre,Xabier Agirre,Matt Teater,Cem Meydan,Zhuoning Li,David Poloway,Shenqiu Wang,Daisuke Ennishi,David W. Scott,Kristy R. Stengel,Janice E. Kranz,Edward B. Holson,Sneh Sharma,James W. Young,Chi-Shuen Chu,Robert G. Roeder,Rita Shaknovich,Scott W. Hiebert,Randy D. Gascoyne,Wayne Tam,Olivier Elemento,Hans-Guido Wendel,Ari Melnick +32 more
TL;DR: The findings establish the tumor suppressor function of CRE BBP in GC lymphomas in which CREBBP mutations disable acetylation and result in unopposed deacetylation by BCL6/SMRT/HDAC3 complexes at enhancers of B-cell signaling and immune response genes, suggesting HDAC3-targeted therapy as a precision approach forCREBBP-mutant lymphomas.
Journal ArticleDOI
O-GlcNAcylation regulates EZH2 protein stability and function.
Chi-Shuen Chu,Pei-Wen Lo,Pei-Wen Lo,Yi-Hsien Yeh,Pang-Hung Hsu,Shih-Huan Peng,Shih-Huan Peng,Yu-Ching Teng,Ming-Lun Kang,Chi-Huey Wong,Li-Jung Juan +10 more
TL;DR: It is shown that OGT is required for the trimethylation of histone 3 at K27 to form the product H3K27me3, a process catalyzed by the histone methyltransferase enhancer of zeste homolog 2 (EZH2) in the polycomb repressive complex 2 (PRC2).
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Antioxidant effects of black rice extract through the induction of superoxide dismutase and catalase activities
TL;DR: The ex vivo study revealed that BRE had significantly stronger ability to inhibit LDL oxidation than white rice extract (WRE) and antioxidative effects exerted by BRE are mediated through decreases in free-radical generation as well as increases in SOD and CAT activities both in vitro and in vivo.
Journal ArticleDOI
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma
Patrizia Mondello,Saber Tadros,Matt Teater,Lorena Fontan,Aaron Y. Chang,Neeraj Jain,Huan Yang,Shailbala Singh,Hsia-Yuan Ying,Chi-Shuen Chu,Man Chun John Ma,Eneda Toska,Stefan Alig,Matthew Durant,E. De Stanchina,Sreejoyee Ghosh,Anja Mottok,Loretta J. Nastoupil,Sattva S. Neelapu,Oliver Weigert,Giorgio Inghirami,Jose Baselga Baselga,Anas Younes,Cassian Yee,Ahmet Dogan,David A. Scheinberg,Robert G. Roeder,Ari Melnick,Michael R. Green +28 more
TL;DR: HAC3 inhibition represents a novel mechanism-based immune-epigenetic therapy for CREBBP mutant lymphomas and restored the ability of tumor infiltrating lymphocytes to kill DLBCL cells in an MHC class I and II dependent manner.