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Chia-Che Ho

Bio: Chia-Che Ho is an academic researcher from Asia University (Taiwan). The author has contributed to research in topics: Regeneration (biology) & Calcium silicate. The author has an hindex of 16, co-authored 28 publications receiving 829 citations. Previous affiliations of Chia-Che Ho include I-Shou University & Georgia Institute of Technology.

Papers
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Journal ArticleDOI
TL;DR: The results indicated that the size and yield of PDA nanoparticles, consisting of quinoid and indoline species, were closely related to the pH value of the precursor solution.
Abstract: A facile method was used to prepare polydopamine (PDA) nanoparticles. The effect of the initial pH of the dopamine solution on the formation kinetics, chemical structure, and biocompatibility of PDA nanoparticles was evaluated. Additionally, camptothecin (CPT) was chosen as a model anti-cancer drug with which to evaluate the efficiency of drug loading and release behavior of PDA nanoparticles. The results indicated that the size and yield of PDA nanoparticles, consisting of quinoid and indoline species, were closely related to the pH value of the precursor solution. At a reaction time of 6 h, the uniform particle sizes of PDA nanoparticles were ~400, 250, 150, and 75 nm in solutions with initial pH values of 7.5, 8, 8.5, and 9, respectively, and with corresponding yields of 3, 7, 20, and 34 %. The amounts of CPT loaded in 1 mg of PDA nanoparticles synthesized at pH values of 7.5, 8, 8.5, and 9 for 6 h were 10.85, 11.81, 10.17, and 6.19 μg, respectively. After the first day, 19, 20, 25, and 36 % of the CPT was released from PDA nanoparticles synthesized at pH values of 7.5, 8, 8.5, and 9, respectively, depending on the particle size. The PDA nanoparticles had excellent haemocompatibility: there was no apparent hemolysis, and they did not cause acute toxicity in A549 and HeLa cells. The loading of CPT into PDA nanoparticles significantly reduced the viability of A549 and HeLa cells, comparable to free CPT. It can be concluded that the PDA nanoparticles prepared by our facile method are potential carriers of anticancer drugs for cancer therapy.

170 citations

Journal ArticleDOI
TL;DR: An overview of the recent progress in the PDA-based materials, including synthesis of nanoparticles, capsules, structure-mechanism, physicochemical and biological properties, and medical applications, is provided.
Abstract: Mussel-inspired polydopamine (PDA) has emerged as a promising molecule used for anchoring synthetic and biological substances or forming an adhesive layer onto various substrates for biomedical and nanotechnology applications because of its outstanding properties. This review article provides an overview of the recent progress in the PDA-based materials, including synthesis of nanoparticles, capsules, structure-mechanism, physicochemical and biological properties, and medical applications. Frist, to understand how PDA nanoparticles, capsules and films produce the unique properties is insight on the processing parameters. Next, we highlight what is known regarding the mechanism of self-polymerization and the structure features of dopamine (DA), which is based on the formation of covalent bond or through a combination mode between monomers. The inherent hydrophilicity and adhesive property of PDA with the coexistence of catechol and amine functionalities provide desirable surface characteristics without the need for further modification. Finally, successful applications, such as grafting substances, biomineralization, antifouling and antibacterial coatings, drug/gene delivery, and tissue engineering, reported to date involving PDA will be focused. The future study of PDA to develop novel materials with unique properties is emerging for specific nanomedicine applications.

120 citations

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TL;DR: A hybrid of synthetic materials with cell constituents not only enhances osteogenesis but also stimulates vessel network development in angiogenesis, presenting the fact that 3D printing can be further applied in improving bone tissue regeneration in numerous aspects.

100 citations

Journal ArticleDOI
TL;DR: The state of the art along with new developments and trends in 3D printed functional medical phantoms and 3D bio-printed structures for regenerated tissues and organs are discussed.

90 citations

Journal ArticleDOI
TL;DR: CSCs display advantageously shortened setting times and might have potential for endodontic use, although further tests are necessary to confirm this.

78 citations


Cited by
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01 Jan 2009
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
Abstract: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

942 citations

Journal ArticleDOI
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

785 citations

Journal ArticleDOI
TL;DR: The analysis of the state of the art in the field reveals the presence of innovative techniques for scaffold and material manufacturing that are currently opening the way to the preparation of biomimetic substrates that modulate cell interaction for improved substitution, restoration, retention or enhancement of bone tissue function.

665 citations

Journal ArticleDOI
Chao Zhang1, Yang Ou1, Wen-xi Lei1, Ling-Shu Wan1, Jian Ji1, Zhi-Kang Xu1 
TL;DR: This work reports a strategy to realize the rapid deposition of PDA by using CuSO4/H2O2 as a trigger, and shows the fastest deposition rate reported to date, and the PDA coatings exhibit high uniformity and enhanced stability.
Abstract: Mussel-inspired polydopamine (PDA) deposition offers a promising route to fabricate multifunctional coatings for various materials. However, PDA deposition is generally a time-consuming process, and PDA coatings are unstable in acidic and alkaline media, as well as in polar organic solvents. We report a strategy to realize the rapid deposition of PDA by using CuSO4/H2O2 as a trigger. Compared to the conventional processes, our strategy shows the fastest deposition rate reported to date, and the PDA coatings exhibit high uniformity and enhanced stability. Furthermore, the PDA-coated porous membranes have excellent hydrophilicity, anti-oxidant properties, and antibacterial performance. This work demonstrates a useful method for the environmentally friendly, cost-effective, and time-saving fabrication of PDA coatings.

450 citations

Journal ArticleDOI
TL;DR: A review of relevant studies and recent progress on four levels introduces different types of biomedical materials, and discusses existing problems and development issues with 3D printing that are related to materials and to the construction of extracellular matrix in vitro for medical applications.

400 citations