C
Chiara Pane
Researcher at University of Naples Federico II
Publications - 40
Citations - 498
Chiara Pane is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Medicine & Ataxia. The author has an hindex of 10, co-authored 28 publications receiving 338 citations.
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Journal ArticleDOI
Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
Genki Hayashi,Mittal Jasoliya,Sunil Sahdeo,Francesco Saccà,Chiara Pane,Alessandro Filla,Angela Marsili,Giorgia Puorro,Roberta Lanzillo,Vincenzo Brescia Morra,Gino A Cortopassi +10 more
TL;DR: It is shown that dimethyl fumarate dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans, making DMF the first drug demonstrated to increase mitochondrialBiogenesis with in vivo human dosing.
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A Combined Nucleic Acid and Protein Analysis in Friedreich Ataxia: Implications for Diagnosis, Pathogenesis and Clinical Trial Design
Francesco Saccà,Giorgia Puorro,Antonella Antenora,Angela Marsili,Alessandra Denaro,Raffaele Piro,Pierpaolo Sorrentino,Chiara Pane,Alessandra Tessa,Vincenzo Brescia Morra,Sergio Cocozza,Giuseppe De Michele,Filippo M. Santorelli,Alessandro Filla +13 more
TL;DR: This is the first explorative study on combined frataxin and mRNA levels in PBMCs from a cohort of FRDA patients, carriers and healthy individuals and proved to be diagnostic when comparing cFA with controls resulting in 100% sensitivity and specificity.
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A randomized clinical trial of lithium in multiple system atrophy
Francesco Saccà,Angela Marsili,Mario Quarantelli,Vincenzo Brescia Morra,Arturo Brunetti,Rosa Carbone,Chiara Pane,Giorgia Puorro,Cinzia Valeria Russo,Elena Salvatore,Tecla Tucci,Giuseppe De Michele,Alessandro Filla +12 more
TL;DR: Overall, lithium was not well tolerated, and the trial was stopped by the Data Monitoring Committee, and future studies with lithium in MSA patients are discouraged.
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The EDSS integration with the Brief International Cognitive Assessment for Multiple Sclerosis and orientation tests
Francesco Saccà,Teresa Costabile,Antonio Carotenuto,Roberta Lanzillo,Marcello Moccia,Chiara Pane,Cinzia Valeria Russo,Anna Maria Barbarulo,S. Casertano,Fabiana Rossi,Elisabetta Signoriello,Giacomo Lus,Vincenzo Brescia Morra +12 more
TL;DR: The use of brief neuropsychological tests leads to a more accurate CFS assessment in two-thirds of MS patients, and a more accurately EDSS calculation in 25% of patients with a score ⩽4.0.
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A randomized controlled pilot trial of lithium in spinocerebellar ataxia type 2
Francesco Saccà,Giorgia Puorro,Arturo Brunetti,Giovambattista Capasso,Amedeo Cervo,Sirio Cocozza,Mariafulvia de Leva,Angela Marsili,Chiara Pane,Mario Quarantelli,Cinzia Valeria Russo,Francesco Trepiccione,Giuseppe De Michele,Alessandro Filla,Vincenzo Brescia Morra +14 more
TL;DR: Lithium was well tolerated and reported AEs were similar to those previously described for bipolar disorder patients, and a correctly powered phase III trial is needed to assess if lithium may slow disease progression in SCA2.