C
Chien Shu Chen
Researcher at China Medical University (Taiwan)
Publications - 39
Citations - 1305
Chien Shu Chen is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Xanthine oxidase & Topoisomerase. The author has an hindex of 17, co-authored 39 publications receiving 1167 citations. Previous affiliations of Chien Shu Chen include Chia Nan University of Pharmacy and Science & National Taiwan University.
Papers
More filters
Journal ArticleDOI
Molecular modeling of flavonoids that inhibits xanthine oxidase.
TL;DR: The inhibition of xanthine oxidase activity by various flavonoids was assessed, and from the kinetic analysis suggested that flavonoid bind to the reactive site, and structure-based molecular modeling was performed.
Journal ArticleDOI
Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
Hsiu Chen Lin,Shin Hui Tsai,Chien Shu Chen,Yuan Ching Chang,Yuan Ching Chang,Chi Ming Lee,Zhi Yang Lai,Zhi Yang Lai,Chun Mao Lin +8 more
TL;DR: The hypoxanthine/XO reaction in the DMPO-ESR technique was used to assess the combined effect on enzyme inhibition and ROS suppression by these coumarins, and the results showed that esculetin was the most potent agent among the tested compounds.
Journal ArticleDOI
Nucleosides XI. Synthesis and antiviral evaluation of 5'-alkylthio-5'-deoxy quinazolinone nucleoside derivatives as S-adenosyl-L-homocysteine analogs.
TL;DR: This approach provides a viable alternative synthetic route to 5'-alkylthio-5'-deoxy nucleoside and its 2',3'-O-isopropylidene derivative did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-amino groups were protected by N,N-dimethylaminomethylidenes.
Journal ArticleDOI
An Activity-Based Near-Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues
Ta-Chun Cheng,Steve R. Roffler,Shey Cherng Tzou,Kuo-Hsiang Chuang,Yu-Cheng Su,Yu-Cheng Su,Chih-Hung Chuang,Chien-Han Kao,Chien Shu Chen,I-Hong Harn,Kuan-Yi Liu,Tian-Lu Cheng,Yu-Ling Leu +12 more
TL;DR: Two fluorescent probes for detection of β-glucuronidase activity are developed, one for the NIR range (containing IR-820 dye) and the other for the visible range [containing fluorescein isothiocyanate (FITC)], by utilizing a difluoromethylphenol- glucuronide moiety (TrapG) to trap the fluorochromes in the vicinity of the active enzyme.
Journal ArticleDOI
Constituents from the Formosan apple reduce tyrosinase activity in human epidermal melanocytes.
TL;DR: 3-hydroxyphloretin (7) and catechol (9) were the most active constituents from the Formosan apple; they exhibited anti-oxidant and tyrosinase reducing activities, suggesting their possible use as cosmetic agents.