C
Chien-Yun Hsiang
Researcher at China Medical University (Taiwan)
Publications - 108
Citations - 3291
Chien-Yun Hsiang is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Gene expression & In vivo. The author has an hindex of 33, co-authored 103 publications receiving 2790 citations. Previous affiliations of Chien-Yun Hsiang include Atomic Energy Council & University of California, Riverside.
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Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
TL;DR: Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
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5-Fluorouracil induced intestinal mucositis via nuclear factor-κB activation by transcriptomic analysis and in vivo bioluminescence imaging.
Chung Ta Chang,Chung Ta Chang,Tin-Yun Ho,Ho Lin,Ji An Liang,Hui-Chi Huang,Chia-Cheng Li,Hsin Yi Lo,Shih Lu Wu,Yi Fang Huang,Chien-Yun Hsiang +10 more
TL;DR: It is suggested that NF-κB was the critical molecule associated with the pathogenesis of 5-FU-induced mucositis, and inhibition of NF-σB activity ameliorated the mucosal damage caused by 5-Fluorouracil.
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Berberine suppresses inflammatory agents-induced interleukin-1β and tumor necrosis factor-α productions via the inhibition of IκB degradation in human lung cells
TL;DR: Berberine, the protoberberine alkaloid widely distributed in the plant kingdom, was capable of suppressing inflammatory agents-induced cytokine production in lung cells and suggested the potential role of berberine in the treatment of pulmonary inflammation.
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Toona sinensis and its major bioactive compound gallic acid inhibit LPS-induced inflammation in nuclear factor-κB transgenic mice as evaluated by in vivo bioluminescence imaging.
TL;DR: The anti-inflammatory potential of TS was mediated by the downregulation of NF-κB pathway, and biological pathways associated with metabolism and the immune responses were affected by TS or GA.
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Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice.
TL;DR: It is demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor G M1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice, providing evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.