Ching Shyang Chen

TL;DR: The current evidence from RCTs does not support the use of MLD in preventing or treating lymphedema, and clinical and statistical inconsistencies between the various studies confounded the evaluation of the effect ofMLD on breast-cancer-related lyMPhedema.

TL;DR: The alpha9-nAChR is important for nicotine-induced transformation of normal human breast epithelial cells and triggered precancerous transformation as defined by soft agar assay.

TL;DR: The homeostatic regulation of cyclin D3 has the potential to be a molecular target for antitumor chemotherapeutic or chemopreventive purposes in clinical breast cancer patients.

TL;DR: The data presented here demonstrate that those patients whose tumors highly expressed ENO-1 had a poor prognosis with greater tumor size, poor nodal status, and a shorter disease-free interval, and suggest that downregulation of ENo-1 could be utilized as a novel pharmacological approach for overcoming 4-OHT resistance in breast cancer therapy.

TL;DR: It is observed that breast tumors with higher α9-nAChR mRNA expression levels were associated with the lowest 5-year disease-specific survival rate, and in vitro promoter-binding assays demonstrated that the ER is a major transcription factor that mediates nicotine- and E2-induced up-regulation of α 9-n AChR gene expression in MCF-7 cells.