Chloe Robins

TL;DR: In this paper, a proteome-wide association study (PWAS) of AD was performed, followed by Mendelian randomization and colocalization analysis to identify loci that confer AD risk through their effects on brain protein abundance to provide new insights into AD pathogenesis.

TL;DR: The study provides an updated characterisation of the genetic architecture of the plasma proteome, leveraging population-scale proteomics to provide novel, extensive insights into trans pQTLs across multiple biological domains.

TL;DR: In this article, the authors generated an online brain pQTL resource for 7,376 proteins through the analysis of genetic and proteomic data derived from post-mortem samples of the dorsolateral prefrontal cortex of 330 older adults.

TL;DR: Genetically-wide methylation and expression patterns for ~ 13 k genes are characterized to explore how DNA methylation interacts with gene expression, throughout the genome, andGene Ontology analysis indicates that trans eCpGs are enriched for transcription factor genes and chromatin modifiers, suggesting that some trans ePGs represent the influence of gene networks and higher-order transcriptional control.

TL;DR: The results suggest that the genetic control of mRNA and protein abundance may be substantially distinct and suggests inference concerning protein abundance made from mRNA in human brain should be treated with caution.