C
Choji Oki
Researcher at Nagoya Institute of Technology
Publications - 10
Citations - 144
Choji Oki is an academic researcher from Nagoya Institute of Technology. The author has contributed to research in topics: Cell signaling & Protein subcellular localization prediction. The author has an hindex of 4, co-authored 7 publications receiving 80 citations.
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Journal ArticleDOI
Synthetic Self-Localizing Ligands That Control the Spatial Location of Proteins in Living Cells
Manabu Ishida,Hideaki Watanabe,Kazumasa Takigawa,Yasutaka Kurishita,Choji Oki,Akinobu Nakamura,Itaru Hamachi,Shinya Tsukiji +7 more
TL;DR: It is shown that SLLs bind their target proteins and relocate (tether) them rapidly from the cytoplasm to their targeting sites, thus serving as synthetic protein translocators, thus opening a new direction in the design of small-molecule tools or drugs for cell regulation.
Journal ArticleDOI
Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells.
Akinobu Nakamura,Choji Oki,Kenya Kato,Satoko Fujinuma,Gembu Maryu,Gembu Maryu,Keiko Kuwata,Tatsuyuki Yoshii,Tatsuyuki Yoshii,Michiyuki Matsuda,Kazuhiro Aoki,Kazuhiro Aoki,Shinya Tsukiji +12 more
TL;DR: Orthogonal PM-specific SLIPT systems provide a powerful new platform for multiplexed chemical signal control in living single cells, offering new opportunities for dissecting cell signaling networks and synthetic cell manipulation.
Journal ArticleDOI
Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and Caenorhabditis elegans.
Akinobu Nakamura,Choji Oki,Shunsuke Sawada,Tatsuyuki Yoshii,Tatsuyuki Yoshii,Keiko Kuwata,Andrew K. Rudd,Neal K. Devaraj,Kentaro Noma,Kentaro Noma,Shinya Tsukiji +10 more
TL;DR: This work newly developed a proteolysis-resistant SL, mDcTMP, which allows sustained PM localization of eDHFR-fusion proteins and was applicable to inducing prolonged signal activation and cell differentiation.
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Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells
Hideyuki Nakanishi,Hideyuki Nakanishi,Tatsuyuki Yoshii,Tatsuyuki Yoshii,Shunsuke Kawasaki,Karin Hayashi,Keita Tsutsui,Choji Oki,Shinya Tsukiji,Hirohide Saito +9 more
TL;DR: Two types of photo-controllable translational activation systems that are compatible with modRNAs are developed that will expand the application of mammalian synthetic biology research.
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Intravital imaging identifies the VEGF-TXA2 axis as a critical promoter of PGE2 secretion from tumor cells and immune evasion
Yoshinobu Konishi,Hiroshi Ichise,Tetsuya Watabe,Choji Oki,Shinya Tsukiji,Yoko Hamazaki,Yasuhiro Murakawa,Akifumi Takaori-Kondo,Kenta Terai,Michiyuki Matsuda +9 more
TL;DR: This article showed that VEGF-dependent release of thromboxane A2 (TXA2) triggers Ca2+ transients in tumor cells, culminating in PGE2 secretion and subsequent immune evasion in the early stages of tumorigenesis.