Chotima Böttcher

TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.

TL;DR: Together, the data advocate selective functions of CCR2-expressing myeloid subsets, which could be targeted specifically to modify disease burden in AD.

TL;DR: The phenotypic signature of hu MG was identified, which was distinct from peripheral myeloid cells but was comparable to fresh huMG, and microglia regional heterogeneity was identified.

TL;DR: Two high-dimensional technologies are combined, single-cell RNA-sequencing and time-of-flight mass cytometry, to identify and characterize a previously unappreciated spectrum of transcriptional states in human microglia, identifying a spectrum of microglian phenotypes that are determined by localization, aging and glioblastoma.

TL;DR: Hexosaminidase subunit beta is identified to be specifically expressed by microglia and stable even under inflammatory conditions, and Prinz and colleagues provide valuable new genetic tools to specifically studymicroglia functions in the CNS.