C
Chris Paul
Researcher at Naval Medical Research Center
Publications - 3
Citations - 903
Chris Paul is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 3, co-authored 3 publications receiving 872 citations.
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Journal ArticleDOI
Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites
Stephen L. Hoffman,Lucy M. L. Goh,Thomas C. Luke,Imogene Schneider,Thong P. Le,Denise L. Doolan,Denise L. Doolan,John B. Sacci,John B. Sacci,Patricia de la Vega,Patricia de la Vega,Megan Dowler,Chris Paul,Daniel M. Gordon,José A. Stoute,L. W. Preston Church,Martha Sedegah,Martha Sedegah,D. Gray Heppner,W. Ripley Ballou,Thomas L. Richie +20 more
TL;DR: These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.
Journal ArticleDOI
Plasmodium falciparum-infected Anopheles stephensi inconsistently transmit malaria to humans.
Leland S. Rickman,Trevor R. Jones,Gary W. Long,Scott Paparello,Imogene Schneider,Chris Paul,Richard L. Beaudoin,Stephen L. Hoffman +7 more
TL;DR: Malaria was transmitted to only 5 of 10 volunteers bitten by 1-2 Anopheles stephensi carrying sporozoites of the 3D7 clone of the NF54 strain of Plasmodium falciparum in their salivary glands.
Journal ArticleDOI
Anti-mosquito midgut antibodies block development of plasmodium falciparum and plasmodium vivax in multiple species of anopheles mosquitoes and reduce vector fecundity and survivorship
Altaf A. Lal,Pamela S. Patterson,John B. Sacci,Jefferson A. Vaughan,Chris Paul,William E. Collins,Robert A. Wirtz,Abdu F. Azad +7 more
TL;DR: The results reveal that mosquito midgut-based antibodies have the potential to reduce malaria transmission in a synergistic manner by lowering both vector competence, through transmission-blocking effects on parasite development, and vector abundance, by decreasing mosquito survivorship and egg laying capacity.