Showing papers by "Chris Sander published in 2020"
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TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.
Abstract: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10,11,12,13,14,15,16,17,18.
1,600 citations
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TL;DR: In this article, a search for the electroweak production of charginos and sleptons decaying into final states with two electrons or muons is presented, based on 139.fb$^{-1}$ of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at
Abstract: A search for the electroweak production of charginos and sleptons decaying into final states with two electrons or muons is presented. The analysis is based on 139 fb$^{-1}$ of proton–proton collisions recorded by the ATLAS detector at the Large Hadron Collider at $\sqrt{s}=13$ $\text {TeV}$. Three R-parity-conserving scenarios where the lightest neutralino is the lightest supersymmetric particle are considered: the production of chargino pairs with decays via either W bosons or sleptons, and the direct production of slepton pairs. The analysis is optimised for the first of these scenarios, but the results are also interpreted in the others. No significant deviations from the Standard Model expectations are observed and limits at 95% confidence level are set on the masses of relevant supersymmetric particles in each of the scenarios. For a massless lightest neutralino, masses up to 420 $\text {Ge}\text {V}$ are excluded for the production of the lightest-chargino pairs assuming W-boson-mediated decays and up to 1 $\text {TeV}$ for slepton-mediated decays, whereas for slepton-pair production masses up to 700 $\text {Ge}\text {V}$ are excluded assuming three generations of mass-degenerate sleptons.
272 citations
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TL;DR: A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13TeV recorded with the ATLAS detector.
Abstract: A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ^{+}τ^{-} decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement with the background prediction of the standard model. In the M_{h}^{125} scenario of the minimal supersymmetric standard model, values of tanβ>8 and tanβ>21 are excluded at the 95% confidence level for neutral Higgs boson masses of 1.0 and 1.5 TeV, respectively, where tanβ is the ratio of the vacuum expectation values of the two Higgs doublets.
178 citations
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TL;DR: A search for narrowly resonant new physics using a machine-learning anomaly detection procedure that does not rely on signal simulations for developing the analysis selection and results are complementary to the dedicated searches for the case that B and C are standard model bosons.
Abstract: This Letter describes a search for narrowly resonant new physics using a machine-learning anomaly detection procedure that does not rely on signal simulations for developing the analysis selection. Weakly supervised learning is used to train classifiers directly on data to enhance potential signals. The targeted topology is dijet events and the features used for machine learning are the masses of the two jets. The resulting analysis is essentially a three-dimensional search A→BC, for m_{A}∼O(TeV), m_{B},m_{C}∼O(100 GeV) and B, C are reconstructed as large-radius jets, without paying a penalty associated with a large trials factor in the scan of the masses of the two jets. The full run 2 sqrt[s]=13 TeV pp collision dataset of 139 fb^{-1} recorded by the ATLAS detector at the Large Hadron Collider is used for the search. There is no significant evidence of a localized excess in the dijet invariant mass spectrum between 1.8 and 8.2 TeV. Cross-section limits for narrow-width A, B, and C particles vary with m_{A}, m_{B}, and m_{C}. For example, when m_{A}=3 TeV and m_{B}≳200 GeV, a production cross section between 1 and 5 fb is excluded at 95% confidence level, depending on m_{C}. For certain masses, these limits are up to 10 times more sensitive than those obtained by the inclusive dijet search. These results are complementary to the dedicated searches for the case that B and C are standard model bosons.
89 citations
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TL;DR: In this article, a search for the direct production of the supersymmetric partners of staus (staus) in final states with two hadronically decaying leptons is presented.
Abstract: A search for the direct production of the supersymmetric partners of
τ
-leptons (staus) in final states with two hadronically decaying
τ
-leptons is presented. The analysis uses a dataset of
p
p
collisions corresponding to an integrated luminosity of
139
fb
−
1
, recorded with the ATLAS detector at the Large Hadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of direct production of stau pairs with each stau decaying into the stable lightest neutralino and one
τ
-lepton in simplified models where the two stau mass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidence level for a massless lightest neutralino.
69 citations
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TL;DR: A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented.
Abstract: A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented. Higgs bosons are identified via the diphoton decay channel (H→γγ), and their production in association with a top quark pair (tt[over ¯]H) or single top quark (tH) is studied. The analysis uses 139 fb^{-1} of proton-proton collision data recorded at a center-of-mass energy of sqrt[s]=13 TeV with the ATLAS detector at the Large Hadron Collider. Assuming a CP-even coupling, the tt[over ¯]H process is observed with a significance of 5.2 standard deviations. The measured cross section times H→γγ branching ratio is 1.64_{-0.36}^{+0.38}(stat)_{-0.14}^{+0.17}(sys) fb, and the measured rate for tt[over ¯]H is 1.43_{-0.31}^{+0.33}(stat)_{-0.15}^{+0.21}(sys) times the Standard Model expectation. The tH production process is not observed and an upper limit on its rate of 12 times the Standard Model expectation is set. A CP-mixing angle greater (less) than 43 (-43)° is excluded at 95% confidence level.
68 citations
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TL;DR: It is demonstrated that recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer and older age, previous healthy weight, and no intentional weight loss further elevate this risk.
Abstract: Importance Pancreatic cancer is the third-leading cause of cancer death in the United States; however, few high-risk groups have been identified to facilitate early diagnosis strategies. Objective To evaluate the association of diabetes duration and recent weight change with subsequent risk of pancreatic cancer in the general population. Design, Setting, and Participants This cohort study obtained data from female participants in the Nurses’ Health Study and male participants in the Health Professionals Follow-Up Study, with repeated exposure assessments over 30 years. Incident cases of pancreatic cancer were identified from self-report or during follow-up of participant deaths. Deaths were ascertained through reports from the next of kin, the US Postal Service, or the National Death Index. Data collection was conducted from October 1, 2018, to December 31, 2018. Data analysis was performed from January 1, 2019, to June 30, 2019. Exposures Duration of physician-diagnosed diabetes and recent weight change. Main Outcome and Measures Hazard ratios (HRs) for subsequent development of pancreatic cancer. Results Of the 112 818 women (with a mean [SD] age of 59.4 [11.7] years) and 46 207 men (with a mean [SD] age of 64.7 [10.8] years) included in the analysis, 1116 incident cases of pancreatic cancers were identified. Compared with participants with no diabetes, those with recent-onset diabetes had an age-adjusted HR for pancreatic cancer of 2.97 (95% CI, 2.31-3.82) and those with long-standing diabetes had an age-adjusted HR of 2.16 (95% CI, 1.78-2.60). Compared with those with no weight loss, participants who reported a 1- to 4-lb weight loss had an age-adjusted HR for pancreatic cancer of 1.25 (95% CI, 1.03-1.52), those with a 5- to 8-lb weight loss had an age-adjusted HR of 1.33 (95% CI, 1.06-1.66), and those with more than an 8-lb weight loss had an age-adjusted HR of 1.92 (95% CI, 1.58-2.32). Participants with recent-onset diabetes accompanied by weight loss of 1 to 8 lb (91 incident cases per 100 000 person-years [95% CI, 55-151]; HR, 3.61 [95% CI, 2.14-6.10]) or more than 8 lb (164 incident cases per 100 000 person-years [95% CI, 114-238]; HR, 6.75 [95% CI, 4.55-10.00]) had a substantially increased risk for pancreatic cancer compared with those with neither exposure (16 incident cases per 100 000 person-years; 95% CI, 14-17). Incidence rates were even higher among participants with recent-onset diabetes and weight loss with a body mass index of less than 25 before weight loss (400 incident cases per 100 000 person-years) or whose weight loss was not intentional judging from increased physical activity or healthier dietary choices (334 incident cases per 100 000 person-years). Conclusions and Relevance This study demonstrates that recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer. Older age, previous healthy weight, and no intentional weight loss further elevate this risk.
64 citations
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TL;DR: In this article, a search for heavy neutral Higgs bosons produced in association with one or two b-quarks and decaying to bquark pairs is presented using 27.8 fb(-1) of root s=13 TeV proton-proton collision data.
Abstract: A search for heavy neutral Higgs bosons produced in association with one or two b-quarks and decaying to b-quark pairs is presented using 27.8 fb(-1) of root s=13 TeV proton-proton collision data r ...
53 citations
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TL;DR: In this paper, the first search for non-resonant signals in dielectron and dimuon final states in the mass range above 2 TeV was presented. But the search was restricted to the case of dielectric dielectrons.
Abstract: A search for new physics with non-resonant signals in dielectron and dimuon final states in the mass range above 2 TeV is presented. This is the first search for non-resonant signals in dilepton fi ...
51 citations
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TL;DR: In this article, a search for supersymmetric partners of gluons and quarks is presented, involving signatures with jets and either two isolated leptons (electrons or muons) with the same electric charge.
Abstract: A search for supersymmetric partners of gluons and quarks is presented, involving signatures with jets and either two isolated leptons (electrons or muons) with the same electric charge, or at leas ...
45 citations
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TL;DR: In this article, a study of the trigger performance and comparisons with simulations show that these changes resulted in event selection efficiencies of > 98% for this period, meeting and in some cases exceeding the performance of similar triggers in earlier run periods, while at the same time keeping the necessary bandwidth within acceptable limits.
Abstract: The factor of four increase in the LHC luminosity, from 0.5 × 1034 cm−2s−1 to 2.0 × 1034cm−2s−1, and the corresponding increase in pile-up collisions during the 2015–2018 data-taking period, presented a challenge for the ATLAS trigger, particularly for those algorithms that select events with missing transverse momentum. The output data rate at fixed threshold typically increases exponentially with the number of pile-up collisions, so the legacy algorithms from previous LHC data-taking periods had to be tuned and new approaches developed to maintain the high trigger efficiency achieved in earlier operations. A study of the trigger performance and comparisons with simulations show that these changes resulted in event selection efficiencies of > 98% for this period, meeting and in some cases exceeding the performance of similar triggers in earlier run periods, while at the same time keeping the necessary bandwidth within acceptable limits.
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TL;DR: A search for direct pair production of scalar partners of the top quark (top squarks or scalar third-generation up-type leptoquarks) in the all-hadronic t (t) over bar plus missing transverse momen was conducted in this paper.
Abstract: A search for direct pair production of scalar partners of the top quark (top squarks or scalar third-generation up-type leptoquarks) in the all-hadronic t (t) over bar plus missing transverse momen
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TL;DR: In this article, a search for the Z gamma decay of the Higgs boson, with Z boson decays into pairs of electrons or muons, was presented, using proton-proton collision data at root s = 13 TeV corresponding...
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TL;DR: In this paper, a measurement of observables sensitive to spin correlations in tt¯ production is presented, using 36.1 fb - 1 of pp collision data at s=13 TeV recorded with the ATLAS detector at the Large Hadron Collider.
Abstract: A measurement of observables sensitive to spin correlations in tt¯ production is presented, using 36.1 fb - 1 of pp collision data at s=13 TeV recorded with the ATLAS detector at the Large Hadron Collider. Differential cross-sections are measured in events with exactly one electron and one muon with opposite-sign electric charge as a function of the azimuthal opening angle and the absolute difference in pseudorapidity between the electron and muon candidates in the laboratory frame. The azimuthal opening angle is also measured as a function of the invariant mass of the tt¯ system. The measured differential cross-sections are compared to predictions by several NLO Monte Carlo generators and fixed-order calculations. The observed degree of spin correlation is somewhat higher than predicted by the generators used. The data are consistent with the prediction of one of the fixed-order calculations at NLO, but agree less well with higher-order predictions. Using these leptonic observables, a search is performed for pair production of supersymmetric top squarks decaying into Standard Model top quarks and light neutralinos. Top squark masses between 170 and 230 GeV are largely excluded at the 95% confidence level for kinematically allowed values of the neutralino mass.
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TL;DR: In this article, a test of CP invariance in Higgs boson production via vector-boson fusion is performed in the H →======ττ decay channel using the Optimal Observable method.
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TL;DR: A search for Higgs boson pair production via vector-boson fusion (VBF) in the bbbb final state is carried out with the ATLAS experiment using 126 fb(-1) of proton-proton collision data delivered a...
Abstract: A search for Higgs boson pair production via vector-boson fusion (VBF) in the bbbb final state is carried out with the ATLAS experiment using 126 fb(-1) of proton- proton collision data delivered a ...
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TL;DR: Searches for the Higgs boson were performed using data corresponding to an integrated luminosity of 139 fb(-1) collected with the ATLAS detector in pp collisions as discussed by the authors.
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TL;DR: A search for magnetic monopoles and high-electric-charge objects is presented using 34.4 fb^{-1} of 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015 and 2016, improving by approximately a factor of 5 the constraints on the direct production of magnetic monopole carrying one or two Dirac magnetic charges.
Abstract: A search for magnetic monopoles and high-electric-charge objects is presented using 34.4 fb^{-1} of 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015 and 2016. The considered signature is based upon high ionization in the transition radiation tracker of the inner detector associated with a pencil-shape energy deposit in the electromagnetic calorimeter. The data were collected by a dedicated trigger based on the tracker high-threshold hit capability. The results are interpreted in models of Drell-Yan pair production of stable particles with two spin hypotheses (0 and 1/2) and masses ranging from 200 to 4000 GeV. The search improves by approximately a factor of 5 the constraints on the direct production of magnetic monopoles carrying one or two Dirac magnetic charges and stable objects with electric charge in the range 20≤|z|≤60 and extends the charge range to 60<|z|≤100.
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TL;DR: In this article, a search for long-lived particles decaying into hadrons and at least one muon is presented, where the analysis selects events that pass a muon or missing transverse-momentum trigger and contain a displaced muon track and a displaced vertex.
Abstract: A search for long-lived particles decaying into hadrons and at least one muon is presented. The analysis selects events that pass a muon or missing-transverse-momentum trigger and contain a displaced muon track and a displaced vertex. The analyzed dataset of proton-proton collisions at s=13 TeV was collected with the ATLAS detector and corresponds to 136 fb-1. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to long-lived particle decays that occur in the ATLAS inner detector. Background estimates for Standard Model processes and instrumental effects are extracted from data. The observed event yields are compatible with those expected from background processes. The results are presented as limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model, and interpreted as exclusion limits in scenarios with pair production of long-lived top squarks that decay via a small R-parity-violating coupling into a quark and a muon. Top squarks with masses up to 1.7 TeV are excluded for a lifetime of 0.1 ns, and masses below 1.3 TeV are excluded for lifetimes between 0.01 ns and 30 ns.
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TL;DR: This work lays the foundation for a new experimental method (3Dseq) for protein structure determination, combining evolution experiments with inference of residue interactions from sequence information.
Abstract: Summary Natural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3D structures. Here, we explored generating similar information by experimental evolution, starting from a single gene and performing multiple cycles of in vitro mutagenesis and functional selection in Escherichia coli. We evolved two antibiotic resistance proteins, β-lactamase PSE1 and acetyltransferase AAC6, and obtained hundreds of thousands of diverse functional sequences. Using evolutionary coupling analysis, we inferred residue interaction constraints that were in agreement with contacts in known 3D structures, confirming genetic encoding of structural constraints in the selected sequences. Computational protein folding with interaction constraints then yielded 3D structures with the same fold as natural relatives. This work lays the foundation for a new experimental method (3Dseq) for protein structure determination, combining evolution experiments with inference of residue interactions from sequence information. A record of this paper’s Transparent Peer Review process is included in the Supplemental Information .
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TL;DR: In this article, multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 mu b(-1) of Pb+Pb collisions at root s(NN) = 5.02TeV with the ATLAS detector at the LHC.
Abstract: Multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 mu b(-1) of Pb+Pb collisions at root s(NN) = 5.02TeV with the ATLAS detector at the LHC ...
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TL;DR: In this paper, a fiducial cross-section for the production of top quarks in association with a photon is measured with proton-proton collision data corresponding to an integrated luminosity of 139 fb$^{−1}$.
Abstract: Inclusive and differential cross-sections for the production of top quarks in association with a photon are measured with proton-proton collision data corresponding to an integrated luminosity of 139 fb$^{−1}$. The data were collected by the ATLAS detector at the LHC during Run 2 between 2015 and 2018 at a centre-of-mass energy of 13 TeV. The measurements are performed in a fiducial volume defined at parton level. Events with exactly one photon, one electron and one muon of opposite sign, and at least two jets, of which at least one is b-tagged, are selected. The fiducial cross-section is measured to be $ {39.6}_{-2.3}^{+2.7} $ fb. Differential cross-sections as functions of several observables are compared with state-of-the-art Monte Carlo simulations and next-to-leading-order theoretical calculations. These include cross-sections as functions of photon kinematic variables, angular variables related to the photon and the leptons, and angular separations between the two leptons in the event. All measurements are in agreement with the predictions from the Standard Model.[graphic not available: see fulltext]
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TL;DR: In this article, a search for dijet resonances in events with at least one isolated charged lepton was performed using 139 fb(-1) of root s = 13 TeV proton-proton collision data recorded by the ATLAS detector at the LHC.
Abstract: A search for dijet resonances in events with at least one isolated charged lepton is performed using 139 fb(-1) of root s = 13 TeV proton-proton collision data recorded by the ATLAS detector at the LHC. The dijet invariant-mass (m(jj)) distribution constructed from events with at least one isolated electron or muon is searched in the region 0.22 < m(jj) < 6.3 TeV for excesses above a smoothly falling background from Standard Model processes. Triggering based on the presence of a lepton in the event reduces limitations imposed by minimum transverse momentum thresholds for triggering on jets. This approach allows smaller dijet invariant masses to be probed than in inclusive dijet searches, targeting a variety of new-physics models, for example ones in which a new state is produced in association with a leptonically decaying W or Z boson. No statistically significant deviation from the Standard Model background hypothesis is found. Limits on contributions from generic Gaussian signals with widths ranging from that determined by the detector resolution up to 15% of the resonance mass are obtained for dijet invariant masses ranging from 0.25 TeV to 6 TeV. Limits are set also in the context of several scenarios beyond the Standard Model, such as the Sequential Standard Model, a technicolor model, a charged Higgs boson model and a simplified Dark Matter model.
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TL;DR: A double-differential cross-section measurement of the Lund jet plane is presented using proton-proton collision data collected with the ATLAS detector using jets with transverse momentum above 675 GeV.
Abstract: The prevalence of hadronic jets at the LHC requires that a deep understanding of jet formation and structure is achieved in order to reach the highest levels of experimental and theoretical precision. There have been many measurements of jet substructure at the LHC and previous colliders, but the targeted observables mix physical effects from various origins. Based on a recent proposal to factorize physical effects, this Letter presents a double-differential cross-section measurement of the Lund jet plane using 139 fb^{-1} of sqrt[s]=13 TeV proton-proton collision data collected with the ATLAS detector using jets with transverse momentum above 675 GeV. The measurement uses charged particles to achieve a fine angular resolution and is corrected for acceptance and detector effects. Several parton shower Monte Carlo models are compared with the data. No single model is found to be in agreement with the measured data across the entire plane.
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Ontario Institute for Cancer Research1, Harvard University2, University of Trento3, University of Toronto4, Georgetown University Medical Center5, Brigham and Women's Hospital6, Van Andel Institute7, University of Texas MD Anderson Cancer Center8, NewYork–Presbyterian Hospital9, Cornell University10, University of California, Los Angeles11
TL;DR: The data show poor concordance between pathologic and molecular purity estimates, necessitating caution when interpreting molecular results, and highlight the need for improved assessment of tumor purity and quantitation of its influences on the molecular hallmarks of cancers.
Abstract: PURPOSEThe tumor microenvironment is complex, comprising heterogeneous cellular populations. As molecular profiles are frequently generated using bulk tissue sections, they represent an admixture o...
22 Apr 2020
TL;DR: In this paper, the first observation of the electroweak symmetry breaking process at the Large Hadron Collider with spin one was reported, with an integrated luminosity of 139 fb$^{-1}$ recorded at a centre of mass energy of 13 TeV by the ATLAS detector.
Abstract: Electroweak symmetry breaking explains the origin of the masses of elementary particles via their interactions with the Higgs field. Besides the measurements of the Higgs boson properties, the study of the scattering of massive vector bosons (with spin one) at the Large Hadron Collider allows to probe the nature of electroweak symmetry breaking with an unprecedented sensitivity. Among all processes related to vector-boson scattering, the electroweak production of two jets and a $Z$-boson pair is a rare and important one. This article reports on the first observation of this process using proton-proton collision data corresponding to an integrated luminosity of 139 fb$^{-1}$ recorded at a centre-of-mass energy of 13 TeV by the ATLAS detector. Two different final states originating from the decays of the $Z$-boson pair, one containing four charged leptons and the other containing two charged leptons and two neutrinos, are considered. The hypothesis of no electroweak production is rejected with a statistical significance of 5.5 $\sigma$, and the measured cross-section for electroweak production is consistent with the Standard Model prediction. In addition, cross-sections for inclusive production of a $Z$-boson pair and two jets are reported for the two final states.
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TL;DR: In this paper, the performance of the ATLAS Inner Detector alignment has been studied using pp collision data at s=13TeV collected by the LHC experiment during Run 2 (2015-2018) of the Large Hadron Collider.
Abstract: The performance of the ATLAS Inner Detector alignment has been studied using pp collision data at s=13TeV collected by the ATLAS experiment during Run 2 (2015–2018) of the Large Hadron Collider (LHC). The goal of the detector alignment is to determine the detector geometry as accurately as possible and correct for time-dependent movements. The Inner Detector alignment is based on the minimization of track-hit residuals in a sequence of hierarchical levels, from global mechanical assembly structures to local sensors. Subsequent levels have increasing numbers of degrees of freedom; in total there are almost 750,000. The alignment determines detector geometry on both short and long timescales, where short timescales describe movements within an LHC fill. The performance and possible track parameter biases originating from systematic detector deformations are evaluated. Momentum biases are studied using resonances decaying to muons or to electrons. The residual sagitta bias and momentum scale bias after alignment are reduced to less than ∼0.1TeV-1 and 0.9 × 10 - 3, respectively. Impact parameter biases are also evaluated using tracks within jets.
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TL;DR: In this paper, a measurement of the production of a prompt J/psi meson in association with a W-+/- boson with W−/- -> mu nu and J−psi -> mu(+)mu(-) is presented.
Abstract: A measurement of the production of a prompt J/psi meson in association with a W-+/- boson with W-+/- -> mu nu and J/psi -> mu(+)mu(-) is presented for J/psi transverse momenta in the range 8. ...
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TL;DR: The elliptic flow of muons from the decay of charm and bottom hadrons is measured in pp collisions at sqrt[s]=13 TeV using a data sample with an integrated luminosity of 150’ pb^{-1} recorded by the ATLAS detector at the LHC.
Abstract: The elliptic flow of muons from the decay of charm and bottom hadrons is measured in pp collisions at sqrt[s]=13 TeV using a data sample with an integrated luminosity of 150 pb^{-1} recorded by the ATLAS detector at the LHC. The muons from heavy-flavor decay are separated from light-hadron decay muons using momentum imbalance between the tracking and muon spectrometers. The heavy-flavor decay muons are further separated into those from charm decay and those from bottom decay using the distance-of-closest-approach to the collision vertex. The measurement is performed for muons in the transverse momentum range 4-7 GeV and pseudorapidity range |η|<2.4. A significant nonzero elliptic anisotropy coefficient v_{2} is observed for muons from charm decays, while the v_{2} value for muons from bottom decays is consistent with zero within uncertainties.
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TL;DR: A measurement of the production cross-section of aZboson in association with b-jets, in proton-proton collisions at root s = 13 TeV with the ATLAS experiment at the Large Hadron... is presented in this article.
Abstract: This paper presents a measurement of the production cross-section of aZboson in association withb-jets, in proton-proton collisions at root s = 13 TeV with the ATLAS experiment at the Large Hadron ...