C
Chris Sander
Researcher at Harvard University
Publications - 730
Citations - 273726
Chris Sander is an academic researcher from Harvard University. The author has contributed to research in topics: Large Hadron Collider & Protein structure. The author has an hindex of 178, co-authored 713 publications receiving 233287 citations. Previous affiliations of Chris Sander include Purdue University & University of Leeds.
Papers
More filters
Posted ContentDOI
Integrative analysis of pharmacogenomics in major cancer cell line databases using CellMinerCDB
Vinodh N. Rajapakse,Augustin Luna,Mihoko Yamade,L Loman,Sudir Varma,Margot Sunshine,Francesco Iorio,Fabricio G. Sousa,Fathi Elloumi,Mirit I. Aladjem,Adam G. Thomas,Chris Sander,Kurt W. Kohn,Cyril H. Benes,Mathew J. Garnett,William C. Reinhold,Yves Pommier +16 more
TL;DR: A panel of 41 drugs evaluated in parallel in the NCI-60 and GDSC is reported, supporting drug reproducibility across databases, repositioning of bisacodyl and acetalax for triple negative breast cancer, and identifying novel drug response determinants and genomic signatures for topoisomerase inhibitors and schweinfurthins in development are reported.
Data from: Sequence co-evolution gives 3D contacts and structures of protein complexes
Thomas A. Hopf,Charlotta P I Schärfe,João P. G. L. M. Rodrigues,Anna G. Green,Chris Sander,Alexandre M. J. J. Bonvin,Debora S. Marks +6 more
TL;DR: It is shown that analysis of correlated evolutionary sequence changes across proteins identifies residues that are close in space with sufficient accuracy to determine the three-dimensional structure of the protein complexes.
Posted ContentDOI
Accurate prediction of transmembrane β-barrel proteins from sequences
TL;DR: The major advance is the use of evolutionary couplings from sequence alignments together with the β-strand prediction to ascertain accurate hydrogen bond between theβ-strands that gives rise to the canonical barrel shapes.