C
Chris Sander
Researcher at Harvard University
Publications - 730
Citations - 273726
Chris Sander is an academic researcher from Harvard University. The author has contributed to research in topics: Large Hadron Collider & Protein structure. The author has an hindex of 178, co-authored 713 publications receiving 233287 citations. Previous affiliations of Chris Sander include Purdue University & University of Leeds.
Papers
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Book ChapterDOI
From Sequence Similarity to Structural Homology of Proteins
Chris Sander,Reinhard Schneider +1 more
TL;DR: It is pointed out that the size of the database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations.
Proceedings ArticleDOI
Abstract 2405: Identification of PHLPP as a tumour suppressor reveals the role of pathway feedback compensation in PTEN-mutant prostate cancer progression
Muhan Chen,Christopher P. Pratt,Martha E. Zeeman,N. Schultz,Barry S. Taylor,Audrey K. O’Neill,Mireia Castillo-Martin,Dawid G. Nowak,Adam Naguib,Danielle M. Grace,Jernej Murn,Chris Sander,William L. Gerald,Carlos Cordon-Cardo,Alexandra C. Newton,Brett S. Carver,Lloyd C. Trotman +16 more
TL;DR: It is demonstrated how the p53-response can antagonise co-deletion of PTEN and PHLPP to form a barrier against prostate cancer progression to emphasise the need for careful evaluation of PI 3-Kinase target therapy effects in prostate cancer and highlight the value of genetically engineered mouse models.
Peer ReviewDOI
Author response: Mitochondrial DNA copy number variation across human cancers
Ed Reznik,Martin L. Miller,Yasin Senbabaoglu,Nadeem Riaz,Judy Sarungbam,Satish K. Tickoo,Hikmat Al-Ahmadie,William Lee,Venkatraman E. Seshan,A. Ari Hakimi,Chris Sander +10 more
Posted ContentDOI
Protein Domain Hotspots Reveal Functional Mutations across Genes in Cancer
Martin L. Miller,Ed Reznik,Nicholas P. Gauthier,Bulent Arman Aksoy,Anil Korkut,Jianjiong Gao,Giovanni Ciriello,Nikolaus Schultz,Chris Sander +8 more
TL;DR: The notion of recurrence of mutations from single genes to gene families that share homologous protein domains is extended, lowering the threshold of detection and sharpening the functional interpretation of the impact of mutations, as protein domains more succinctly embody function than entire genes.
Posted ContentDOI
Targeting Adaptation to Cancer Treatment by Drug Combinations
Heping Wang,Augustin Luna,Augustin Luna,Gonghong Yan,Xubin Li,Özgün Babur,Mills Gb,Chris Sander,Chris Sander,Anil Korkut +9 more
TL;DR: In this paper, the authors provide the mathematical formulation, implementation and validation of the TargetScore method, which identifies collective adaptive responses to targeted interventions as concurrent changes of phospho-proteins that are connected within a signaling network.