Chris Sander

TL;DR: This study compares the performance of 13 established network inference methods in their capacity to retrieve literature-curated pathway interactions from RPPA data and reveals that signal transduction events involving receptor tyrosine kinases, the RAS/MAPK pathway, and the PI3K/AKT/mTOR pathway are the most significant PPIs shared across all tumor types.

TL;DR: Cell type-specific network models of signaling in RAF-inhibitor resistant melanoma cells are reported, showing that co-targeting c-Myc, using the BET bromodomain inhibitor JQ1, and the RAF/MEK pathway, using kinase inhibitors is both effective and synergistic in this context.

TL;DR: Collaborative efforts combining computational biology, structural biology and statistical physics expertise provide a solution to the computational protein folding problem.

TL;DR: The histologic grade of myxoid liposarcoma is determined by the extent of the round cell (RC) component, and for this study, MRLS was defined as having a round cell component.

TL;DR: In this article , the authors apply evolutionary models of sequence co-variation to computationally design highly divergent variants of the model protein TEM-1 β-lactamase, and characterize these designs experimentally using multiple biochemical and biophysical assays.