Chris Sander

TL;DR: Direct evidence is presented that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and a role for miR-124 in long-term plasticity of synapses in the mature nervous system is presented.

TL;DR: The three‐dimensional structure of hexokinase is known and can be used to build models of functionally important regions of other kinases in this family, which contains many prokaryotic and eukaryotic sugar kinases with diverse specificities, including a new member, rhamnokinase from Salmonella typhimurium.

TL;DR: The ACC mutational landscape is determined and the exome or whole-genome sequences of 60 ACC tumor-normal pairs are reported, finding mutations in genes encoding chromatin-state regulators, suggesting that there is aberrant epigenetic regulation in ACC oncogenesis.

TL;DR: This work proposes a framework for joint modeling of discrete and continuous variables that arise from integrated genomic, epigenomic, and transcriptomic profiling, motivated by the hypothesis that diverse molecular phenotypes can be predicted by a set of orthogonal latent variables that represent distinct molecular drivers, and thus can reveal tumor subgroups of biological and clinical importance.

TL;DR: In 62 proteins with 10,000 residues, it is found that the longest isolated homologies between unrelated proteins are five residues long, which shows quantitatively that pentapeptide structure within a protein is strongly dependent on sequence context.