C
Chris Sander
Researcher at Harvard University
Publications - 730
Citations - 273726
Chris Sander is an academic researcher from Harvard University. The author has contributed to research in topics: Large Hadron Collider & Protein structure. The author has an hindex of 178, co-authored 713 publications receiving 233287 citations. Previous affiliations of Chris Sander include Purdue University & University of Leeds.
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Journal ArticleDOI
Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development
Daniel P. Leaman,Po Yu Chen,John J. Fak,Abdullah Yalcin,Michael C. Pearce,Ulrich Unnerstall,Debora S. Marks,Chris Sander,Thomas Tuschl,Ulrike Gaul +9 more
TL;DR: It is demonstrated that injection of 2'O-methyl antisense oligoribonucleotides into early Drosophila embryos leads to specific and efficient depletion of microRNAs and thus permits systematic loss-of-function analysis in vivo.
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Database algorithm for generating protein backbone and side-chain co-ordinates from a C alpha trace application to model building and detection of co-ordinate errors.
Liisa Holm,Chris Sander +1 more
TL;DR: This work presents an automatic procedure for generating full protein co-ordinates (backbone and, optionally, side-chains) given the C alpha trace and amino acid sequence and demonstrates its accuracy on X-ray structures determined at better than 2.5 A resolution.
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Quality control of protein models : directional atomic contact analysis
Gerrit Vriend,Chris Sander +1 more
TL;DR: In this article, a contact quality index is defined as a measure of the agreement between the distributions of atoms around each residue fragment in the model and equivalent distributions derived from the database of known structures solved at high resolution.
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RNA targets of wild-type and mutant FET family proteins
Jessica I. Hoell,Erik Larsson,Simon Runge,Jeffrey Nusbaum,Sujitha Duggimpudi,Thalia A. Farazi,Markus Hafner,Arndt Borkhardt,Chris Sander,Thomas Tuschl +9 more
TL;DR: Using PAR-CLIP, global RNA targets for all human FET proteins and two ALS-causing human FUS mutants were defined and FET members showed similar binding profiles, whereas F US mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization.
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Pathway and network analysis of cancer genomes
Pau Creixell,Jueri Reimand,Syed Haider,Guanming Wu,Tatsuhiro Shibata,Miguel Vazquez,Ville Mustonen,Abel Gonzalez-Perez,John V. Pearson,Chris Sander,Rune Linding +10 more
TL;DR: An overview of pathway and network analysis methods that group genes and illuminate the processes involved in tumor biology are provided and where they guide mechanistic and translational investigations are shown.