C
Chris Sander
Researcher at Harvard University
Publications - 730
Citations - 273726
Chris Sander is an academic researcher from Harvard University. The author has contributed to research in topics: Large Hadron Collider & Protein structure. The author has an hindex of 178, co-authored 713 publications receiving 233287 citations. Previous affiliations of Chris Sander include Purdue University & University of Leeds.
Papers
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Journal ArticleDOI
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2
Nikolaus Schultz,Dina R Marenstein,Dino A. De Angelis,Weiqing Wang,Sven Nelander,Sven Nelander,Anders Jacobsen,Debora S. Marks,Joan Massagué,Chris Sander +9 more
TL;DR: It is suggested that the type II TGF-β receptor is regulated by multiple miRNAs, and the risk of obtaining misleading results in siRNA screens using large libraries with single-assay readout is substantial.
Proceedings Article
GeneQuiz: a workbench for sequence analysis.
Michael Scharf,Reinhard Schneider,Georg Casari,Peer Bork,Alfonso Valencia,Christos A. Ouzounis,Chris Sander +6 more
TL;DR: The prototype of a software system, called GeneQuiz, for large-scale biological sequence analysis, is presented and an overview of the architecture of the system prototype and the experiences on its applicability in sequence analysis are covered.
Journal ArticleDOI
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
E. Zeynep Erson-Omay,Ahmet Okay Caglayan,Nikolaus Schultz,Nils Weinhold,S. Bulent Omay,Koray Özduman,Yavuz Köksal,Jie Li,Akdes Serin Harmanci,Victoria E. Clark,Geneive Carrión-Grant,Jacob F Baranoski,Caner Çağlar,Tanyeri Barak,Süleyman Coşkun,Burçin Baran,Doğan Köse,Jia Sun,Mehmet Bakırcıoğlu,Jennifer Moliterno Günel,M. Necmettin Pamir,Ketu Mishra-Gorur,Kaya Bilguvar,Katsuhito Yasuno,Alexander O. Vortmeyer,Anita Huttner,Chris Sander,Murat Gunel +27 more
TL;DR: A genomically, histologically, and clinically distinct subgroup of HGGs that harbored somatic POLE mutations and carried an improved prognosis is identified.
Journal ArticleDOI
Immunization with synthetic peptides of a Plasmodium falciparum surface antigen induces antimerozoite antibodies
Andrew Cheung,Johann Leban,Alan R. Shaw,B Merkli,J W Stocker,Carlo Chizzolini,Chris Sander,Luc Perrin +7 more
TL;DR: Structural analysis of the deduced polypeptides suggests that peptide 3 is exposed at the surface of merozoites, and three of the four animals used to immunize monkeys were partially protected from a challenge infection that induced a fulminant infection in control animals.
Journal ArticleDOI
The normal modes of a protein: Native bovine pancreatic trypsin inhibitor
TL;DR: In this article, a general treatment of normal mode analysis is developed that can be used with any potential energy function and any set of generalized coordinates, and applied to the calculation of the normal modes of the small protein bovine pancreatic trypsin inhibitor.