Chris Sander

TL;DR: It is proposed that one mode of chaperone action is to actively unfold misfolded or badly aggregated proteins to a conformation from which they could refold spontaneously, and that the molecular mechanism for unfolding is either repeated binding and dissociation ('plucking') or translocation of the protein backbone through a binding cleft ('threading'), allowing the threaded chain to refolds spontaneously.

TL;DR: A hybrid approach is developed combining sparse NMR data with evolutionary residue-residue couplings and accurate structure determination for several proteins 6−41 kDa in size is demonstrated.

TL;DR: A model of the GDP state of ras‐p21 that is in agreement with all relevant experimental evidence is proposed and provides important clues about a possible molecular mechanism for signal transmission from the site of GTP hydrolysis to downstream effectors.

TL;DR: A genomic analysis of GENCODE lnc RNAs in high-grade serous ovarian adenocarcinoma based on The Cancer Genome Atlas (TCGA) molecular profiles shows that intergenic lncRNAs can be specifically targeted by somatic copy-number amplification, suggestive of functional involvement in tumor initiation or progression.