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Christel Gozzi

Bio: Christel Gozzi is an academic researcher from École supérieure de chimie physique électronique de Lyon. The author has contributed to research in topics: Aryl & Thiophene. The author has an hindex of 14, co-authored 37 publications receiving 4003 citations. Previous affiliations of Christel Gozzi include Conservatoire national des arts et métiers & Claude Bernard University Lyon 1.

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TL;DR: Symmetrical functionalized biaryls and biheterocycles could be obtained in good yield via homocoupling of aryl halides by using Pd(OAc)2 as catalyst with base and isopropanol as discussed by the authors.

135 citations

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TL;DR: Ureas were synthesized from methyl carbamates which were obtained by reaction of amines with dimethyl carbonate as mentioned in this paper, both reactions were catalyzed by γ-Al2O3.

110 citations

Journal ArticleDOI
TL;DR: In this paper, the Heck-type reaction with the mixture of Pd(OAc) 2 and n-Bu 4 NBr as a catalytic system was applied to different derivatives and proved to be compatible with sensitive functional groups.

98 citations

Journal ArticleDOI
TL;DR: In this article, the Heck-type reaction with Pd(OAc) 2 NBu 4 Br as catalytic system was reported, where the substitution is regiospecific when the heterocycle is 2-substituted with an electron withdrawing group.

95 citations


Cited by
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TL;DR: s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to make organic preparations.
Abstract: s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to

3,373 citations

Journal ArticleDOI
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Abstract: The biaryl structural motif is a predominant feature in many pharmaceutically relevant and biologically active compounds. As a result, for over a century 1 organic chemists have sought to develop new and more efficient aryl -aryl bond-forming methods. Although there exist a variety of routes for the construction of aryl -aryl bonds, arguably the most common method is through the use of transition-metalmediated reactions. 2-4 While earlier reports focused on the use of stoichiometric quantities of a transition metal to carry out the desired transformation, modern methods of transitionmetal-catalyzed aryl -aryl coupling have focused on the development of high-yielding reactions achieved with excellent selectivity and high functional group tolerance under mild reaction conditions. Typically, these reactions involve either the coupling of an aryl halide or pseudohalide with an organometallic reagent (Scheme 1), or the homocoupling of two aryl halides or two organometallic reagents. Although a number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps. In particular, the obligation to use coupling partners that are both activated is wasteful since it necessitates the installation and then subsequent disposal of stoichiometric activating agents. Furthermore, preparation of preactivated aryl substrates often requires several steps, which in itself can be a time-consuming and economically inefficient process.

3,204 citations

01 Jan 2007
TL;DR: The Third edition of the Kirk-Othmer encyclopedia of chemical technology as mentioned in this paper was published in 1989, with the title "Kirk's Encyclopedia of Chemical Technology: Chemical Technology".
Abstract: 介绍了Kirk—Othmer Encyclopedia of Chemical Technology(化工技术百科全书)(第五版)电子图书网络版数据库,并对该数据库使用方法和检索途径作出了说明,且结合实例简单地介绍了该数据库的检索方法。

2,666 citations