C
Christian Andresen
Researcher at University of Düsseldorf
Publications - 9
Citations - 1046
Christian Andresen is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Titin & Obscurin. The author has an hindex of 8, co-authored 8 publications receiving 919 citations. Previous affiliations of Christian Andresen include University of Münster & Ruhr University Bochum.
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Journal ArticleDOI
Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs
Martina Krüger,Sebastian Kötter,Anika Grützner,Patrick Lang,Christian Andresen,Margaret M. Redfield,Elke Butt,Cris dos Remedios,Wolfgang A. Linke +8 more
TL;DR: Reducing titin stiffness by PKG-dependent phosphorylation of the N2-Bus can benefit diastolic function, and phosphorylated titin sites could affect protein–protein interactions.
Journal ArticleDOI
Isoform Diversity of Giant Proteins in Relation to Passive and Active Contractile Properties of Rabbit Skeletal Muscles
Lucas G. Prado,Irina G. Makarenko,Christian Andresen,Martina Krüger,Christiane A. Opitz,Wolfgang A. Linke +5 more
TL;DR: A low correlation exists between the active and passive mechanical properties of skeletal muscle fibers and titin, which contributes substantially to total passive stiffness, but this contribution varies greatly among muscles.
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Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization
Laura T. Donlin,Christian Andresen,Steffen Just,Eugene Rudensky,Christopher T. Pappas,Martina Krüger,Erica Y. Jacobs,Andreas Unger,Anke Zieseniss,Marc-Werner Dobenecker,Tobias Voelkel,Brian T. Chait,Carol C. Gregorio,Wolfgang Rottbauer,Alexander Tarakhovsky,Wolfgang A. Linke +15 more
TL;DR: A cytoplasmic protein network that employs lysine methylation for the maintenance and function of skeletal muscle is revealed and deficiency in Smyd2 results in the loss of Hsp90 methylation, impaired titin stability, and altered muscle function.
Journal ArticleDOI
Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function
Tobias Voelkel,Christian Andresen,Andreas Unger,Steffen Just,Wolfgang Rottbauer,Wolfgang A. Linke +5 more
TL;DR: It is concluded that Smyd2 and presumably several other Smyd family members are lysine methyltransferases which have, next to their nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells.
Journal ArticleDOI
Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1
Anna-Eliane Hopf,Christian Andresen,Sebastian Kötter,Malgorzata Isić,Kamila Ulrich,Senem Sahin,Sabine Bongardt,Wilhelm Röll,Felicitas Drove,Nina Scheerer,Leni Vandekerckhove,Gilles W. De Keulenaer,Nazha Hamdani,Wolfgang A. Linke,Martina Krüger +14 more
TL;DR: Chronic NRG-1 application is a promising approach to modulate titin properties in heart failure with preserved ejection fraction associated with type-2 diabetes mellitus by restoring normal kinase activities of PKG, ERK1/2, and PKC&agr;, and by reducing cardiomyocyte passive tension.