C
Christian Becker
Researcher at University of Mainz
Publications - 102
Citations - 6017
Christian Becker is an academic researcher from University of Mainz. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 37, co-authored 94 publications receiving 5330 citations. Previous affiliations of Christian Becker include Max Delbrück Center for Molecular Medicine & University of Münster.
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Journal ArticleDOI
Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression
Tobias Bopp,Christian Becker,Matthias Klein,Stefan Klein-Heßling,Alois Palmetshofer,Edgar Serfling,Valeska Heib,Marc Becker,Jan Kubach,Steffen Schmitt,Sabine Stoll,Hansjörg Schild,Martin S. Staege,Michael Stassen,Helmut Jonuleit,Edgar Schmitt +15 more
TL;DR: It is shown that naturally occurring T reg cells harbor high levels of cyclic adenosine monophosphate (cAMP), a second messenger is known to be a potent inhibitor of proliferation and interleukin 2 synthesis in T cells and traverses membranes via gap junctions.
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Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation.
Anita Rauch,Juliane Hoyer,Sabine Guth,Christiane Zweier,Cornelia Kraus,Christian Becker,Martin Zenker,Ulrike Hüffmeier,Christian Thiel,Franz Rüschendorf,Peter Nürnberg,André Reis,Udo Trautmann +12 more
TL;DR: The diagnostic yield of conventional karyotyping, subtelomeric screening, molecular karyotypes, X‐inactivation studies, and dysmorphological evaluation with targeted laboratory testing in unselected patients referred for developmental delay or mental retardation is analyzed.
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Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Philip Wenzel,Maike Knorr,Sabine Kossmann,Jan Stratmann,Michael Hausding,Swenja Schuhmacher,Susanne Karbach,Melanie Schwenk,Nir Yogev,Eberhard Schulz,Matthias Oelze,Stephan Grabbe,Helmut Jonuleit,Christian Becker,Andreas Daiber,Ari Waisman,Thomas Münzel +16 more
TL;DR: Infiltrating monocytes with a proinflammatory phenotype and macrophages rather than neutrophils appear to be essential for ATII-induced vascular dysfunction and arterial hypertension.
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Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.
Louise A. Metherell,J. Paul Chapple,Sadani N. Cooray,Alessia David,Christian Becker,Franz Rüschendorf,Danielle Naville,Martine Begeot,Bernard Khoo,Peter Nürnberg,Angela Huebner,Michael E. Cheetham,Adrian J. L. Clark +12 more
TL;DR: It is shown that MRAP interacts withMC2R and may have a role in the trafficking of MC2R from the endoplasmic reticulum to the cell surface and may be involved in the Trafficking of melanocortin 2 receptor accessory protein (MRAP).
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Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.
Toszka Bohn,Steffen Rapp,Natascha Luther,Matthias Klein,Till-Julius Bruehl,Nobuhiko Kojima,Pamela Aranda Lopez,Jennifer Hahlbrock,Sabine Muth,Shogo Endo,Stefanie Pektor,Almut Brand,Kathrin Renner,Vanessa Popp,Katharina Gerlach,Dennis Vogel,Christina Lueckel,Christina Lueckel,Danielle Arnold-Schild,Jacques Pouysségur,Marina Kreutz,Magdalena Huber,Jochem Koenig,Benno Weigmann,Hans Christian Probst,Esther von Stebut,Christian Becker,Hansjoerg Schild,Edgar Schmitt,Tobias Bopp +29 more
TL;DR: It is demonstrated that highly glycolytic tumors acidify their microenvironment and use this to initiate a mechanism of localized immunosuppression and identify a molecular mechanism of metabolic communication between non-lymphoid tissue and the immune system that was exploited by high-glycolysis-rate tumors for evasion of the immuneSystem.