Christian Benedict

TL;DR: Results indicate a direct action of prolonged intranasal administration of insulin on brain functions, improving memory and mood in the absence of systemic side effects, which could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease.

TL;DR: Molecular mechanisms potentially underlying the memory-enhancing and neuroprotective effects of intranasal insulin are presented and an overview of neuroimaging studies indicating that disturbances in insulin metabolism and altered brain responses to insulin are linked to decreased cerebral volume and especially to hippocampal atrophy is provided.

TL;DR: Test the hypothesis that acute sleep loss decreases physical activity while increasing food intake, thereby shifting 2 crucial behavioral components of energy homeostasis toward weight gain, and short-term sleep loss neither increased food intake nor affected concentrations of the hunger-regulating hormones leptin and ghrelin.

TL;DR: Results indicate that insulin-induced memory improvement can be enhanced by using rapid-acting insulin analog insulin aspart (ASP-I), and may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

TL;DR: The results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex.