C
Christian Höner zu Siederdissen
Researcher at Leipzig University
Publications - 45
Citations - 4339
Christian Höner zu Siederdissen is an academic researcher from Leipzig University. The author has contributed to research in topics: RNA & Rfam. The author has an hindex of 14, co-authored 42 publications receiving 3445 citations. Previous affiliations of Christian Höner zu Siederdissen include University of Copenhagen & Max Planck Society.
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Journal ArticleDOI
ViennaRNA Package 2.0
Ronny Lorenz,Stephan H. Bernhart,Christian Höner zu Siederdissen,Hakim Tafer,Christoph Flamm,Peter F. Stadler,Ivo L. Hofacker,Ivo L. Hofacker +7 more
TL;DR: In this article, exact dynamic programming algorithms can be used to compute ground states, base pairing probabilities, as well as thermodynamic properties of nucleic acids based on carefully measured thermodynamic parameters.
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Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering
Matthias Hackl,Tobias Jakobi,Jochen Blom,Daniel Doppmeier,Karina Brinkrolf,Rafael Szczepanowski,Stephan H. Bernhart,Christian Höner zu Siederdissen,Juan A. Hernandez Bort,Matthias Wieser,Renate Kunert,Simon A. Jeffs,Ivo L. Hofacker,Alexander Goesmann,Alfred Pühler,Nicole Borth,Johannes Grillari +16 more
TL;DR: Deep-sequencing small RNA fractions of 6 biotechnologically relevant cell lines and cDNA sequencing of 26 validated targets of miR-17-92 suggests conserved functions for miRNAs in CHO cells, which together with the now publicly available sequence information sets the stage for developing novel RNAi tools for CHO cell engineering.
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Predicting RNA 3D structure using a coarse-grain helix-centered model.
TL;DR: This work proposes that given the wide range of conformational space that needs to be explored, a coarse-grain approach can explore more conformations in less iterations than an all-atom model coupled to a fine-grain energy function.
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A folding algorithm for extended RNA secondary structures
TL;DR: A theoretical model capturing both RNA pair families and extended secondary structure motifs with shared nucleotides using 2-diagrams is presented, accompanying this model with a number of programs for parameter optimization and structure prediction.
Journal ArticleDOI
2D Meets 4G: G-Quadruplexes in RNA Secondary Structure Prediction
Ronny Lorenz,Stephan H. Bernhart,Jing Qin,Christian Höner zu Siederdissen,Andrea Tanzer,Fabian Amman,Ivo L. Hofacker,Peter F. Stadler +7 more
TL;DR: With preliminary energy parameters, it is found that the overwhelming majority of putative quadruplex-forming sequences in the human genome are likely to fold into canonical secondary structures instead.