C
Christian Rosenmund
Researcher at Charité
Publications - 172
Citations - 24116
Christian Rosenmund is an academic researcher from Charité. The author has contributed to research in topics: Synaptic vesicle & Neurotransmission. The author has an hindex of 71, co-authored 171 publications receiving 21733 citations. Previous affiliations of Christian Rosenmund include University of Texas Southwestern Medical Center & Howard Hughes Medical Institute.
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Journal ArticleDOI
Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses
TL;DR: It is found that hypertonic solutions do not act through changes in intracellular calcium, which means that the synaptic release probability depends on the size of the readily releasable pool.
Journal ArticleDOI
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Hsiao-Tuan Chao,Hongmei Chen,Rodney C. Samaco,Mingshan Xue,Mingshan Xue,Maria H. Chahrour,Jong Yoo,Jeffrey L. Neul,Shiaoching Gong,Hui-Chen Lu,Nathaniel Heintz,Marc Ekker,John L.R. Rubenstein,Jeffrey L. Noebels,Christian Rosenmund,Christian Rosenmund,Huda Y. Zoghbi +16 more
TL;DR: It is shown that mice lacking Mecp2 from GABA-releasing neurons recapitulate numerous Rett syndrome and autistic features, including repetitive behaviours, and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes.
Journal ArticleDOI
Synaptotagmin I functions as a calcium regulator of release probability
Rafael Fernández-Chacón,Andreas Königstorfer,Stefan H. Gerber,Jesus Ricardo Alvarado Garcia,Maria F. Matos,Charles F. Stevens,Nils Brose,Josep Rizo,Christian Rosenmund,Thomas C. Südhof +9 more
TL;DR: A point mutation in synaptotagmin I is studied that causes a twofold decrease in overall Ca2+ affinity without inducing structural or conformational changes and participates in triggering neurotransmitter release at the synapse.
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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
Monika Piwecka,Petar Glažar,Luis R. Hernandez-Miranda,Sebastian Memczak,Susanne A. Wolf,Agnieszka Rybak-Wolf,Andrei Filipchyk,Filippos Klironomos,Cledi Alicia Cerda Jara,Pascal Fenske,Thorsten Trimbuch,Vera Zywitza,Mireya Plass,Luisa Schreyer,Salah Ayoub,Christine Kocks,Ralf Kühn,Christian Rosenmund,Carmen Birchmeier,Nikolaus Rajewsky +19 more
TL;DR: It is suggested that neuronal Cdr1as stabilizes or transports miR-7, which in turn represses genes that are early responders to different stimuli, and that CDR1as modulates neuronal activity in the human brain.
Journal ArticleDOI
The tetrameric structure of a glutamate receptor channel
Christian Rosenmund,Yael Stern-Bach,Yael Stern-Bach,Yael Stern-Bach,Charles F. Stevens,Charles F. Stevens,Charles F. Stevens +6 more
TL;DR: Successful application of a counting method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels.