C
Christian Werner
Researcher at University of Mainz
Publications - 237
Citations - 7202
Christian Werner is an academic researcher from University of Mainz. The author has contributed to research in topics: Cerebral blood flow & Ischemia. The author has an hindex of 42, co-authored 228 publications receiving 6627 citations. Previous affiliations of Christian Werner include Ottawa Hospital & Technische Universität München.
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Journal ArticleDOI
Pathophysiology of traumatic brain injury
TL;DR: Understanding the multidimensional cascade of secondary brain injury offers differentiated therapeutic options.
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Dexmedetomidine Improves Neurologic Outcome from Incomplete Ischemia in the Rat Reversal by the α2-Adrenergic Antagonist Atipamezole
TL;DR: It is concluded that alpha 2-adrenoreceptor stimulation decreases sympathetic activity and decreases ischemic injury in a model of incomplete cerebral ischemia in rats.
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The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.
Kristin Engelhard,Christian Werner,Eva Eberspächer,Monika Bachl,Manfred Blobner,Eberhard Hildt,Peter Hutzler,Eberhard Kochs +7 more
TL;DR: It is possible that the neuroprotective properties of dexmedetomidine and S(+)-ketamine seen in previous studies involve ultra-early modulation of the balance between pro- and antiapoptotic proteins.
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The Effects of Propofol on Brain Electrical Activity, Neurologic Outcome, and Neuronal Damage Following Incomplete Ischemia in Rats
Eberhard Kochs,William E. Hoffman,Christian Werner,Chinamma Thomas,Ronald F. Albrecht,Jochen Schulte am Esch +5 more
TL;DR: Results show that propofol improves neurologic outcome and decreases neuronal damage from incomplete cerebral ischemia when compared to fentanyl/N2O.
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Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
William E. Hoffman,Dale A. Pelligrino,Christian Werner,Eberhard Kochs,Ronald F. Albrecht,Jochem Schulte am Esch +5 more
TL;DR: It is suggested that ketamine improves neurologic outcome from incomplete cerebral ischemia by a mechanism related to a decrease in plasma catecholamine activity.