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Christiane E. Wobus
Researcher at University of Michigan
Publications - 152
Citations - 10080
Christiane E. Wobus is an academic researcher from University of Michigan. The author has contributed to research in topics: Murine norovirus & Norovirus. The author has an hindex of 43, co-authored 132 publications receiving 8740 citations. Previous affiliations of Christiane E. Wobus include Washington University in St. Louis & Michigan State University.
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Journal ArticleDOI
Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
Christiane E. Wobus,Stephanie M. Karst,Larissa B. Thackray,Kyeong-Ok Chang,Stanislav V. Sosnovtsev,Gaël Belliot,Anne Krug,Jason M. Mackenzie,Kim Y. Green,Herbert W. Virgin +9 more
TL;DR: The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into Norovirus biology.
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STAT1-Dependent Innate Immunity to a Norwalk-Like Virus
TL;DR: Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1–dependent innate immunity, but not T and B cell–dependent adaptive immunity, is essential for norovirus resistance.
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Enteric bacteria promote human and mouse norovirus infection of B cells.
Melissa K. Jones,Makiko Watanabe,Shu Zhu,Christina L. Graves,Lisa R. Keyes,Katrina R. Grau,Mariam B. Gonzalez-Hernandez,Nicole M. Iovine,Christiane E. Wobus,Jan Vinjé,Scott A. Tibbetts,Shannon M. Wallet,Stephanie M. Karst +12 more
TL;DR: B cells are identified as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development of an in vitro infection model for human norovIRuses.
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Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis
TL;DR: This chapter discusses human noroviruses, which are the major cause of nonbacterial, epidemic gastroenteritis worldwide and cause significant numbers of endemic cases, as well as investigating the mechanisms behind their spread.
Journal ArticleDOI
Identification of a Heparin-Binding Motif on Adeno-Associated Virus Type 2 Capsids
Andrea Kern,K. Schmidt,Christoph Leder,Oliver J. Müller,Christiane E. Wobus,K. Bettinger,C W von der Lieth,J. A. King,J. A. King,Jürgen A. Kleinschmidt +9 more
TL;DR: Results suggest that although heparin binding influences the infectivity of AAV-2, it seems not to be necessary.