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Christina E. Barkauskas
Researcher at Duke University
Publications - 33
Citations - 4834
Christina E. Barkauskas is an academic researcher from Duke University. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 14, co-authored 26 publications receiving 3761 citations. Previous affiliations of Christina E. Barkauskas include Baylor University Medical Center & Durham University.
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Journal ArticleDOI
Type 2 alveolar cells are stem cells in adult lung
Christina E. Barkauskas,Michael J. Cronce,Craig R. Rackley,Emily Bowie,Douglas R. Keene,Barry R. Stripp,Barry R. Stripp,Scott H. Randell,Paul W. Noble,Paul W. Noble,Brigid L.M. Hogan +10 more
TL;DR: A combination of in vivo clonal lineage analysis, different injury/repair systems, and in vitro culture of purified cell populations is used to obtain new information about the contribution of AEC2s to alveolar maintenance and repair.
Journal ArticleDOI
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
Jason R. Rock,Christina E. Barkauskas,Michael J. Cronce,Yan Xue,Jeffrey R. Harris,Jiurong Liang,Paul W. Noble,Brigid L.M. Hogan +7 more
TL;DR: A previously unappreciated heterogeneity of cell types proliferating in fibrotic lesions is shown and pericytes and two epithelial cell populations are excluded as the origin of myofibroblasts.
Journal ArticleDOI
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Brigid L.M. Hogan,Christina E. Barkauskas,Harold A. Chapman,Jonathan A. Epstein,Rajan Jain,Connie C. W. Hsia,Laura E. Niklason,Elizabeth A. Calle,Andrew V. Le,Scott H. Randell,Jason R. Rock,Melinda Snitow,Matthew F. Krummel,Barry R. Stripp,Thiennu H. Vu,Eric S. White,Jeffrey A. Whitsett,Edward E. Morrisey +17 more
TL;DR: The multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair are highlighted.
Journal ArticleDOI
Pulmonary fibrosis: patterns and perpetrators
TL;DR: Understanding the heterogeneity of these diseases and elucidating the final common pathways of fibrogenesis are critical for the development of efficacious therapies for severe fibrosing lung diseases.
Journal ArticleDOI
Lung organoids: current uses and future promise.
Christina E. Barkauskas,Mei-I Chung,Bryan A. Fioret,Xia Gao,Hiroaki Katsura,Brigid L.M. Hogan +5 more
TL;DR: This Review summarizes the different methods for generating organoids from cells isolated from human and mouse lungs, and compares their final structure and cellular composition with that of the airways or alveoli of the adult lung.