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Christina R. Wilson

Bio: Christina R. Wilson is an academic researcher from Purdue University. The author has contributed to research in topics: Taxus & Glycoproteomics. The author has an hindex of 8, co-authored 18 publications receiving 317 citations.

Papers
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Journal ArticleDOI
01 Feb 2001-Toxicon
TL;DR: Current investigations suggest that taxine alkaloids chief action is on cardiac myocytes resulting in heart failure and death in instances of animal and human poisoning.

170 citations

Journal ArticleDOI
TL;DR: It was found that PrP d deposits in a single case were consistent with atypical scrapie, and a method was developed to obtain a PrP genotype from FFPE tissues and was applied to material from this single case, which was shown to be AHQ/AHQ.
Abstract: Atypical scrapie is a relatively recent discovery, and it was unknown whether it was a new phenomenon or whether it had existed undetected in the United Kingdom national flock. Before 1998, the rou...

32 citations

Journal ArticleDOI
TL;DR: High-performance liquid chromatography analysis indicated that there are three different chemotypes of white snakeroot from the plant samples analyzed, and elucidation of these chemotypes may explain the sporadic and unpredictable toxicity of white Snakeroot to livestock and humans.
Abstract: Ingestion of white snakeroot (Ageratina altissima) can cause trembles in livestock and milk sickness in humans. The toxicity has been associated with tremetol, a relatively crude, multicomponent lipophilic extract of the plant. In this study, 11 different compounds were isolated from white snakeroot-derived lipophilic extracts from 18 collections. Six of the isolated compounds have not been previously reported to be found in white snakeroot. High-performance liquid chromatography (HPLC) analysis indicated that there are three different chemotypes of white snakeroot from the plant samples analyzed. Elucidation of these chemotypes may explain the sporadic and unpredictable toxicity of white snakeroot to livestock and humans.

28 citations

Book ChapterDOI
01 Jan 2012
TL;DR: Improvements in analytical toxicology have made chemical confirmation of the taxine alkaloids in diagnostic cases possible, and the primary treatment for exposed mammals primarily involves symptomatic and supportive care.
Abstract: Yew plant intoxication has been implicated in numerous animal and human poisoning cases. The poisonous nature of the yew plant ( Taxus spp.) is attributed to the presence of cardiotoxic taxine alkaloids. The mechanism of action of taxine alkaloids involves calcium channel antagonism in cardiac myocytes. Ultimately, these toxins cause cardiac dysrhythmias and rapid onset of adverse clinical signs, often ending in death. Diagnosis of yew poisoning is frequently based on history of exposure or identification of yew plant fragments in the digestive tract; however, improvements in analytical toxicology have made chemical confirmation of the taxine alkaloids in diagnostic cases possible. In suspect cases of yew intoxication, the primary treatment for exposed mammals primarily involves symptomatic and supportive care.

21 citations

Journal ArticleDOI
TL;DR: Significant differences between the IC(50) values of murine and rat microsomes suggest differences in the susceptibility of these species to warfarin.

18 citations


Cited by
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Journal ArticleDOI
TL;DR: This new edition includes more than 107,000 terms and definitions, including new consultants for the specialties of endocrinology, gastroenterology, geriatrics, and rheumatology.
Abstract: This new edition includes more than 107,000 terms and definitions, more than 5,000 new to this edition. More than 45 consultants from all the major medical and health science specialties have reviewed each word for accuracy and clarity, including new consultants for the specialties of endocrinology, gastroenterology, geriatrics, and rheumatology. The art program has also been extensively enhanced and now includes approximately 1,500 images and illustrations.

537 citations

Journal ArticleDOI
TL;DR: An overview of the recent advances in mass spectrometry based glycoproteomic methods and technology, in the context of biomarker discovery and clinical application is provided.

248 citations

Journal ArticleDOI

246 citations

Journal ArticleDOI
TL;DR: This contribution aims to review the most important mechanisms of various abiotic and biotic interactions, such as pathogenic microorganisms and herbivory, by which plants respond to exogenous influences, and will also report on time-scale variable influences on secondary metabolite profiles.

212 citations