Christine Marzano

TL;DR: The effects of auranofin, a gold(I) compound clinically used as an antirheumatic agent, on cisplatin-sensitive (2008) and-resistant (C13*) cancer cells were studied and its action is particularly marked in C13* cells, indicating that no cross-resistance occurs.

TL;DR: Gold(III) derivatives of N,N-dimethyldithiocarbamate and ethylsarcosinedithiOCarbamate have been proved to be much more cytotoxic in vitro than cisplatin, with IC50 values about 1- to 4-fold lower than that of the reference drug, even toward human tumor cell lines intrinsically resistant to cis platin itself.

TL;DR: These gold(III) complexes show high reactivity toward some biologically important isolated macromolecules, resulting in a dramatic inhibition of both DNA and RNA synthesis and inducing DNA lesions with a faster kinetics than cisplatin, suggesting that intracellular DNA might not represent their primary or exclusive biological target.

TL;DR: In this paper, the synthesis, characterization and biological activity of new coordination compounds of the type [M(TSDTM)X 2 ] (M=Pt(II), Pd(II); X=Cl, Br; TSDTM= ter-butylsarcosine(S -methyl)dithiocarbamate) and [Pd(TSDT)X] n (TSDT= ter -butyl sarcosinedithIocaramate) in order to study their behavior as potential antitumor agents.

TL;DR: The preliminary biological evaluation has shown that the replacement of the acridine moiety with the analogous 2-oxo-2H-pyrano[2,3-b]quinoline system drastically reduced both their anticancer activity and their propency to intercalate into double stranded DNA.