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Christine Vande Velde
Researcher at Université de Montréal
Publications - 59
Citations - 7822
Christine Vande Velde is an academic researcher from Université de Montréal. The author has contributed to research in topics: Stress granule & SOD1. The author has an hindex of 31, co-authored 54 publications receiving 7046 citations. Previous affiliations of Christine Vande Velde include University of Manitoba & University of California, San Diego.
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Journal ArticleDOI
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi,Paul N. Valdmanis,Patrick A. Dion,Dan Spiegelman,Brendan J. McConkey,Christine Vande Velde,Jean-Pierre Bouchard,Lucette Lacomblez,Ksenia Pochigaeva,François Salachas,Pierre-François Pradat,William Camu,Vincent Meininger,Nicolas Dupré,Nicolas Dupré,Guy A. Rouleau +15 more
TL;DR: Findings further corroborate that TDP-43 is involved in ALS pathogenesis and reports eight missense mutations in nine individuals—six from individuals with sporadic ALS and three from those with familial ALS (FALS)—and a concurring increase of a smaller T DP-43 product.
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ALS: a disease of motor neurons and their nonneuronal neighbors.
TL;DR: In this paper, a mutant superoxide dismutase (SOD1) was found to induce non-cell-autonomous motor neuron killing by an unknown gain of toxicity.
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Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria
Jian Liu,Concepción Lillo,P. Andreas Jonsson,Christine Vande Velde,Christopher M. Ward,Timothy M. Miller,Jamuna R. Subramaniam,Jeffery D. Rothstein,Stefan L. Marklund,Peter M. Andersen,Thomas Brännström,Ole Gredal,Philip C. Wong,David S. Williams,Don W. Cleveland +14 more
TL;DR: Findings implicate damage from action of spinal cord-specific factors that recruit mutant SOD1 to spinal mitochondria as the basis for their selective toxicity in ALS.
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Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Edor Kabashi,Li Lin,Miranda L. Tradewell,Patrick A. Dion,Valérie Bercier,Patrick Bourgouin,Daniel Rochefort,Samar Bel Hadj,Heather D. Durham,Christine Vande Velde,Guy A. Rouleau,Pierre Drapeau +11 more
TL;DR: Together these approaches showed that TARDBP mutations cause motor neuron defects and toxicity, suggesting that both a toxic gain of function as well as a novel loss of function may be involved in the molecular mechanism by which mutant TDP-43 contributes to disease pathogenesis.
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BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites
Reena Ray,Gao Chen,Christine Vande Velde,Jeannick Cizeau,Jae Hoon Park,John C. Reed,R. Daniel Gietz,Arnold H. Greenberg +7 more
TL;DR: It is proposed that BNIP3 represents a subfamily of Bcl-2-related proteins that functions without a typical BH3 domain to regulate apoptosis from both mitochondrial and nonmitochondrial sites by selective B cl-2/Bcl-XL interactions.