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Christoph Hafemeister
Researcher at New York University
Publications - 30
Citations - 16050
Christoph Hafemeister is an academic researcher from New York University. The author has contributed to research in topics: Gene regulatory network & Gene. The author has an hindex of 16, co-authored 27 publications receiving 7388 citations. Previous affiliations of Christoph Hafemeister include National Institutes of Health & Max Planck Society.
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Journal ArticleDOI
Selecting Oligonucleotide Probes for Whole-Genome Tiling Arrays with a Cross-Hybridization Potential
TL;DR: This work proposes the first computationally efficient method using hybridization energy to identify specific oligonucleotide probes, and obtains very favorable results in comparison with prior approaches with respect to specificity and sensitivity for cross-hybridization and genome coverage with high-specificity probes.
Posted ContentDOI
Environmental gene regulatory influence networks in rice (Oryza sativa): response to water deficit, high temperature and agricultural environments
TL;DR: TFA estimation using network component analysis is an effective way of incorporating multiple genome-scale measurements into network inference and that supplementing data from controlled experimental conditions with data from outdoor field conditions increases the resolution for EGRIN inference.
Posted ContentDOI
Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators
Ingrid M. Saldana-Guerrero,Luis F Montano-Gutierrez,Christoph Hafemeister,Dylan Stavish,Lisa E. Shaw,Irfete S. Fetahu,Andrea Wenninger-Weinzierl,Caterina Sturtzel,Celine Souilhol,Sophia Tarelli,Mohamed R. Shoeb,Marie Bernkopf,Polyxeni Bozatzi,Maria Guarini,Eva Bozsaky,Michelle Buri,Eva Maria Putz,Peter W. Andrews,Ivana Barbaric,Helen E. Bryant,Martin Distel,Sabine Taschner-Mandl,Matthias Farlik,Anestis Tsakiridis,Florian Halbritter +24 more
TL;DR: In this article , the effects of chromosome 17q/1q gains in the embryonal tumour neuroblastoma (NB) were investigated using human embryonic stem cell (hESC) differentiation and showed that CNVs impair the specification of hESC-derived trunk neural crest (NC) cells and their sympathoadrenal derivatives.
Journal ArticleDOI
Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis.
Sevgi Kostel Bal,S. Giuliani,Jana Block,Peter Repiščák,Christoph Hafemeister,Tala Shahin,Nurhan Aruçi Kasap,Cheryl van de Wetering,Alexandra Frohne,Raul Jimenez-Heredia,Michael Schuster,Samaneh Zoghi,Marini Thian,Aleksandr Bykov,Royala Babayeva,Sevgi Bilgic Eltan,Elif Karakoc-Aydiner,Lisa E. Shaw,Markku Varjosalo,Rafael J. Argüello,Matthias Farlik,Ahmet Ozen,Edgar Serfling,Loïc Dupré,Christoph Bock,Florian Halbritter,J. Thomas Hannich,Irinka Castanon,Michael J Kraakman,Safa Baris,Kaan Boztug +30 more
TL;DR: The NFAT family of transcription factors plays central roles in adaptive immunity in murine models, however, their contribution to human immune homeostasis remains poorly defined as discussed by the authors , and the role of NFATc1 in human immunity beyond receptor signaling is poorly defined.
Posted ContentDOI
Single-cell RNA-seq differential expression tests within a sample should use pseudo-bulk data of pseudo-replicates
TL;DR: In this paper , the best combinations of data transformations and statistical test methods were examined for single-cell RNA sequencing (scRNA-seq) data and pseudo-bulk approaches were evaluated in single-sample designs.