Author
Christoph Stein
Other affiliations: Humboldt University of Berlin, National Institute on Drug Abuse, California State University, Long Beach ...read more
Bio: Christoph Stein is an academic researcher from Charité. The author has contributed to research in topics: Opioid & Opioid peptide. The author has an hindex of 77, co-authored 259 publications receiving 19430 citations. Previous affiliations of Christoph Stein include Humboldt University of Berlin & National Institute on Drug Abuse.
Topics: Opioid, Opioid peptide, Opioid receptor, Analgesic, Receptor
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms, and provide specific recommendations for use of these medications.
Abstract: Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism–based approach.
1,229 citations
TL;DR: These studies indicate that the immune system can interact with peripheral sensory-nerve endings to inhibit pain and intrinsic modulation of nociception can occur at the peripheral terminals of afferent nerves.
Abstract: Pain can be effectively diminished by various endogenous mechanisms within the central nervous system One region where these mechanisms have been well characterized is the dorsal horn of the spina
695 citations
TL;DR: Recently, evidence has begun to accumulate that opioid antinociception can be initiated by activation of opioid receptors located outside the central nervous system (CNS) as discussed by the authors, which is the earliest evidence that opioids exert analgesic effects through actions outside the CNS.
Abstract: Traditionally, opioids exert analgesic effects through actions within the central nervous system (CNS) exclusively (1) Recently, however, evidence has begun to accumulate that opioid antinociception can be initiated by activation of opioid receptors located outside the CNS One of the earliest repo
603 citations
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
575 citations
TL;DR: The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects, but research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide–containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
Abstract: The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide-containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
570 citations
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28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
3,394 citations
2,819 citations
TL;DR: The view that addiction is the pathology that results from an allostatic mechanism using the circuits established for natural rewards provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and relapse.
2,678 citations
TL;DR: The present review focuses on the organisation of descending pathways and their pathophysiological significance, the role of individual transmitters and specific receptor types in the modulation and expression of mechanisms of descending inhibition and facilitation and the advantages and limitations of established and innovative analgesic strategies which act by manipulation of descending controls.
2,565 citations