C
Christophe Antoniewski
Researcher at University of Paris
Publications - 69
Citations - 5031
Christophe Antoniewski is an academic researcher from University of Paris. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 32, co-authored 62 publications receiving 4576 citations. Previous affiliations of Christophe Antoniewski include National Institute for Medical Research & University of Nice Sophia Antipolis.
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Journal ArticleDOI
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
Julien Colombani,Laurence Bianchini,Laurence Bianchini,Laurence Bianchini,Sophie Layalle,Sophie Layalle,Sophie Layalle,Emilie Pondeville,Emilie Pondeville,Emilie Pondeville,Chantal Dauphin-Villemant,Chantal Dauphin-Villemant,Chantal Dauphin-Villemant,Christophe Antoniewski,Christophe Antoniewski,Christophe Antoniewski,Clément Carré,Clément Carré,Clément Carré,Stéphane Noselli,Stéphane Noselli,Stéphane Noselli,Pierre Léopold,Pierre Léopold,Pierre Léopold +24 more
TL;DR: It is demonstrated that the larval fat body, equivalent to the vertebrate liver, is a key relay element for ecdysone-dependent growth inhibition and forms a humoral regulatory loop that determines organismal size.
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The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster.
Ronald P. van Rij,Maria-Carla Saleh,Bassam Berry,Catherine K. Foo,Andrew R. Houk,Christophe Antoniewski,Raul Andino +6 more
TL;DR: The central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster.
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The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.
Safia Deddouche,Nicolas Matt,Aidan Budd,Stefanie Mueller,Cordula Kemp,Delphine Galiana-Arnoux,Delphine Galiana-Arnoux,Catherine Dostert,Catherine Dostert,Christophe Antoniewski,Jules A. Hoffmann,Jean-Luc Imler +11 more
TL;DR: Genetic evidence is provided that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus.
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Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila.
Jean-Yves Roignant,Clément Carré,Bruno Mugat,Dimitri Szymczak,Jean-Antoine Lepesant,Christophe Antoniewski +5 more
TL;DR: The results provide evidence that transitive and systemic aspects of RNAi are not conserved in Drosophila and demonstrate that dsRNA-producing transgenes allow powerful reverse genetic approaches to be conducted in this model organism, by knocking down gene functions at the resolution of a single-cell type and of asingle isoform.
Journal ArticleDOI
Antiviral immunity in Drosophila requires systemic RNA interference spread
Maria-Carla Saleh,Maria-Carla Saleh,Michel Tassetto,Ronald P. van Rij,Ronald P. van Rij,Bertsy Goic,Valérie Gausson,Bassam Berry,Bassam Berry,Caroline Jacquier,Caroline Jacquier,Christophe Antoniewski,Christophe Antoniewski,Raul Andino +13 more
TL;DR: It is shown that a recently defined double-stranded RNA (dsRNA) uptake pathway is essential for effective antiviral RNAi immunity in adult flies, and that spread of dsRNA to uninfected sites is essential.