C
Christophe Heymes
Researcher at French Institute of Health and Medical Research
Publications - 99
Citations - 8751
Christophe Heymes is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Heart failure & Nitric oxide synthase. The author has an hindex of 43, co-authored 99 publications receiving 8138 citations. Previous affiliations of Christophe Heymes include King's College London & Centre national de la recherche scientifique.
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Journal ArticleDOI
Increased myocardial NADPH oxidase activity in human heart failure.
Christophe Heymes,Jennifer K. Bendall,Philippe Ratajczak,Alison C. Cave,Jane-Lise Samuel,Gerd Hasenfuss,Ajay M. Shah +6 more
TL;DR: The increase in NADPH oxidase activity in the failing heart may be important in the pathophysiology of cardiac dysfunction by contributing to increased oxidative stress.
Journal ArticleDOI
Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.
TL;DR: A gp91phox-containing NADPH oxidase plays an important role in the development of angiotensin II-induced cardiac hypertrophy, independent of changes in blood pressure.
Journal ArticleDOI
Myocardial Production of Aldosterone and Corticosterone in the Rat PHYSIOLOGICAL REGULATION
Jean-Sébastien Silvestre,Valérie Robert,Christophe Heymes,Brigitte Aupetit-Faisant,Christian Mouas,J. M. Moalic,Bernard Swynghedauw,Claude Delcayre +7 more
TL;DR: This study provides the first evidence for the existence of an endocrine cardiac steroidogenic system in rat heart and emphasizes its potential physiological and pathological relevance.
Journal ArticleDOI
Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques.
TL;DR: It is suggested that in vivo local shear stress influences luminal endothelial cell apoptosis and may be a major determinant of plaque erosion and thrombosis.
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Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.
Lesley Hoyles,José Manuel Fernández-Real,Massimo Federici,Matteo Serino,Matteo Serino,James Abbott,Julie Charpentier,Julie Charpentier,Christophe Heymes,Christophe Heymes,Jèssica Latorre Luque,Elodie Anthony,Richard H. Barton,Julien Chilloux,Antonis Myridakis,Laura Martinez-Gili,José María Moreno-Navarrete,Fadila Benhamed,Vincent Azalbert,Vincent Azalbert,Vincent Blasco-Baque,Vincent Blasco-Baque,Josep Puig,Gemma Xifra,Wifredo Ricart,Christopher Tomlinson,Mark Woodbridge,Marina Cardellini,Francesca Davato,Iris Cardolini,Ottavia Porzio,Ottavia Porzio,Paolo Gentileschi,Frédéric Lopez,Frédéric Lopez,Fabienne Foufelle,Sarah Butcher,Elaine Holmes,Jeremy K. Nicholson,Catherine Postic,Rémy Burcelin,Rémy Burcelin,Marc-Emmanuel Dumas +42 more
TL;DR: It is demonstrated that fecal microbiota transplants and chronic treatment with phenylacetic acid, a microbial product of aromatic amino acids metabolism, successfully trigger steatosis and branched-chain amino acid metabolism.